A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi. (Q39580084)

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24 January 2020

title

A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi (English)

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24 January 2020

1

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24 January 2020

author name string

Linghu Nie

2

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24 January 2020

Meghna Das Thakur

3

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24 January 2020

Qin Su

4

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24 January 2020

Zhenfen Chi

5

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24 January 2020

Yongliang Zhao

6

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24 January 2020

Gregory D Longmore

7

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24 January 2020

publication date

1 December 2010

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Genomics Proteomics and Bioinformatics

24 January 2020

published in

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24 January 2020

volume

8

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24 January 2020

issue

4

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24 January 2020

page(s)

238-245

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Cancer regression in patients after transfer of genetically engineered lymphocytes

24 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

A2A adenosine receptor protects tumors from antitumor T cells.

14 September 2017

1 reference

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Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Off-target effects by siRNA can induce toxic phenotype

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

RNA interference: a potential therapeutic tool for silencing splice isoforms linked to human diseases.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Induction of the interferon response by siRNA is cell type- and duplex length-dependent

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Unlocking the potential of the human genome with RNA interference

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Functional siRNAs and miRNAs Exhibit Strand Bias

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Mice deficient in alpha-actinin-4 have severe glomerular disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Prevalence of off-target effects in Drosophila RNA interference screens

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Mismatched siRNAs downregulate mRNAs as a function of target site location.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

siRNA-directed inhibition of HIV-1 infection

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Retraction of synapses and dendritic spines induced by off-target effects of RNA interference.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Synthetic shRNAs as potent RNAi triggers.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5054148

10.1016/S1672-0229(10)60025-3

21 August 2018

Identifiers

DOI

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journals/gpb/FengNTSCZL10

24 January 2020

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382592%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference