Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors (Q39583739)

13 September 2017

Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors (English)

1 reference

13 September 2017

Beverly L Falcon

1

1 reference

13 September 2017

Sharon Barr

2

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13 September 2017

Prafulla C Gokhale

3

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13 September 2017

Jeyling Chou

4

1 reference

13 September 2017

Jennifer Fogarty

5

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13 September 2017

Philippe Depeille

6

1 reference

13 September 2017

Mark Miglarese

7

1 reference

13 September 2017

David M Epstein

8

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13 September 2017

Donald M McDonald

9

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13 September 2017

language of work or name

English

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publication date

1 March 2011

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13 September 2017

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13 September 2017

71

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13 September 2017

1573-1583

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5

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describes a project that uses

13 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3077087/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels

14 September 2017

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14 September 2017

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Dissecting the role of mTOR: lessons from mTOR inhibitors

14 September 2017

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Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

14 September 2017

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Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase

14 September 2017

1 reference

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

14 September 2017

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

14 September 2017

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Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability

14 September 2017

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

14 September 2017

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The PTEN-PI3K pathway: of feedbacks and cross-talks

14 September 2017

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Defining the role of mTOR in cancer

14 September 2017

1 reference

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Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression

14 September 2017

1 reference

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The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy

14 September 2017

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14 September 2017

mTOR and cancer therapy

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Rapid vascular regrowth in tumors after reversal of VEGF inhibition

14 September 2017

1 reference

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Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

14 September 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

14 September 2017

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

14 September 2017

1 reference

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Cellular abnormalities of blood vessels as targets in cancer

14 September 2017

1 reference

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

14 September 2017

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

14 September 2017

1 reference

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Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts

14 September 2017

1 reference

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mTOR-mediated regulation of translation factors by amino acids

14 September 2017

1 reference

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Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

14 September 2017

1 reference

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Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

Openings between defective endothelial cells explain tumor vessel leakiness

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

14 September 2017

1 reference

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Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice

14 September 2017

1 reference

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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

14 September 2017

1 reference

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A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

14 September 2017

1 reference

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo

14 September 2017

1 reference

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Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors

14 September 2017

1 reference

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OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models

14 September 2017

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Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

14 September 2017

1 reference

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Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

High-throughput screening for mTORC1/mTORC2 kinase inhibitors using a chemiluminescence-based ELISA assay

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077087

VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21363918

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-10-3126

1 reference

13 September 2017

1 reference

13 September 2017

1 reference