The PTEN-PI3K pathway: of feedbacks and cross-talks (Q34828662)

4 August 2017

The PTEN-PI3K pathway: of feedbacks and cross-talks (English)

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4 August 2017

A Carracedo

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4 August 2017

P P Pandolfi

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

1 September 2008

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5527-5541

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4 August 2017

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https://scigraph.springernature.com/pub.10.1038/onc.2008.247

4 August 2017

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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1 reference

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Negative regulation of the forkhead transcription factor FKHR by Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Identification of a tumour suppressor network opposing nuclear Akt function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Ubiquitination regulates PTEN nuclear import and tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Suppression of PTEN expression by NF-kappa B prevents apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Phosphoinositide 3-kinase-dependent activation of Rac.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Functional inhibition of PI3K by the betaGBP molecule suppresses Ras-MAPK signalling to block cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Muscle-specific Pten deletion protects against insulin resistance and diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Phosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

PI3K pathway alterations in cancer: variations on a theme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Class I PI3K in oncogenic cellular transformation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

Phosphorylation and regulation of Raf by Akt (protein kinase B)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.247

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.247

1 reference

Dimensions Publication ID

4 August 2017

0 references

1 reference