Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. (Q39597798)

13 September 2017

Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. (English)

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13 September 2017

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Yun Sang Lee

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13 September 2017

Ahjoku Amadi-Obi

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2

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13 September 2017

Cheng-Rong Yu

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13 September 2017

Charles E Egwuagu

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13 September 2017

7 February 2011

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13 September 2017

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13 September 2017

132

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4

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13 September 2017

492-502

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Bench to bedside: new approaches to the immunotherapy of uveitic disease

13 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

The natural history of uveitis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): potential neuroprotective role of SOCS proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

IL-27 limits IL-2 production during Th1 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Negative regulators of cytokine signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Twenty proteins containing a C-terminal SOCS box form five structural classes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2010.03379.X

Interleukin-10 and cAMP-elevating agents cooperate to induce suppressor of cytokine signaling-3 via a protein kinase A-independent signal

21 January 2018

1 reference

12 December 2020

Cytokine-induced retinal degeneration: role of suppressors of cytokine signaling (SOCS) proteins in protection of the neuroretina

1 reference

12 December 2020

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells

1 reference

12 December 2020

Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling

1 reference

12 December 2020

Standardization of vitreal inflammatory activity in intermediate and posterior uveitis

1 reference

12 December 2020

Proctor Lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications

1 reference

12 December 2020

Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice.

1 reference

12 December 2020

10.1111/J.1365-2567.2010.03379.X

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DOI

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13 September 2017

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