ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. (Q39614082)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400128%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors (English)

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18 March 2020

1 reference

1 reference

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18 March 2020

Bryan E Thacker

7

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18 March 2020

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Jeffrey D Esko

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18 March 2020

author name string

Ryan Nock

2

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18 March 2020

Ni-Huiping Son

3

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18 March 2020

Bastian Ramms

4

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18 March 2020

Irene Lew

5

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18 March 2020

Jon C Gonzales

6

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18 March 2020

Debapriya Basu

8

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18 March 2020

Richard G Lee

9

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18 March 2020

Adam E Mullick

10

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18 March 2020

Mark J Graham

11

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18 March 2020

Ira J Goldberg

12

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18 March 2020

Rosanne M Crooke

13

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18 March 2020

Joseph L Witztum

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18 March 2020

language of work or name

English

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publication date

11 July 2016

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Journal of Clinical Investigation

18 March 2020

published in

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18 March 2020

volume

126

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18 March 2020

page(s)

2855-2866

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18 March 2020

issue

8

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The risk of cardiovascular events with increased apolipoprotein CIII: A systematic review and meta-analysis

18 March 2020

cites work

1 reference

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14 September 2017

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Triglycerides and cardiovascular disease

14 September 2017

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Loss-of-function mutations in APOC3 and risk of ischemic vascular disease

14 September 2017

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Loss-of-function mutations in APOC3, triglycerides, and coronary disease

14 September 2017

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The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

14 September 2017

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Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets

14 September 2017

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Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice

14 September 2017

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Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans

14 September 2017

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Apolipoprotein E in VLDL and LDL with apolipoprotein C-III is associated with a lower risk of coronary heart disease

14 September 2017

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Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans

14 September 2017

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Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology

14 September 2017

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Human apolipoprotein C-III - a new intrahepatic protein factor promoting assembly and secretion of very low density lipoproteins

14 September 2017

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Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice

14 September 2017

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Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

14 September 2017

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Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake

14 September 2017

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Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype

14 September 2017

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Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice

14 September 2017

1 reference

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Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions

14 September 2017

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A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection

14 September 2017

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Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

14 September 2017

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Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice

14 September 2017

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Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice

14 September 2017

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Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

14 September 2017

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Chylomicronemia due to apolipoprotein CIII overexpression in apolipoprotein E-null mice. Apolipoprotein CIII-induced hypertriglyceridemia is not mediated by effects on apolipoprotein E

14 September 2017

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14 September 2017

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Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice

14 September 2017

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Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia

14 September 2017

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Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein

14 September 2017

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Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver

14 September 2017

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Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo

14 September 2017

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Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles

14 September 2017

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Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase.

14 September 2017

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Apolipoprotein C-II and C-III levels in hyperlipoproteinemia

14 September 2017

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Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice.

14 September 2017

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Targeting APOC3 in the familial chylomicronemia syndrome

25 September 2017

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Familial deficiency of apolipoproteins A-I and C-III and precocious coronary-artery disease

17 June 2018

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Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein

17 June 2018

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Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

17 June 2018

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Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype

21 August 2018

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Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice

21 August 2018

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Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction

21 August 2018

1 reference

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Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein

2 December 2018

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12 December 2020

Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice

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12 December 2020

Low nonfasting triglycerides and reduced all-cause mortality: a mendelian randomization study

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12 December 2020

Lipoprotein lipase activity and mRNA levels in bovine tissues

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12 December 2020

Density gradient ultracentrifugation of serum lipoproteins in a swinging bucket rotor

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12 December 2020

Identifiers

DOI

10.1172/JCI86610

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400128%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400128%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference