Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia (Q39619066)

13 September 2017

Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia (English)

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13 September 2017

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13 September 2017

3

Steven L Wesselingh

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13 September 2017

Daniel Cowley

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PubMed ID

21165788

13 September 2017

Paul R Gorry

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4

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PubMed ID

21165788

13 September 2017

Melissa J Churchill

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5

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13 September 2017

30 November 2010

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13 September 2017

Journal of NeuroVirology

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13 September 2017

17

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13 September 2017

1

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13 September 2017

70-81

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https://scigraph.springernature.com/pub.10.1007/s13365-010-0002-5

13 September 2017

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CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable

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HIV-1 Tat protein mimicry of chemokines

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Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription

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Updated research nosology for HIV-associated neurocognitive disorders

21 January 2018

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Inhibition of human immunodeficiency virus reactivation from latency by a tat transdominant negative mutant.

21 January 2018

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Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation

21 January 2018

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Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis.

21 January 2018

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Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity

21 January 2018

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HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region

21 January 2018

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Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport

21 January 2018

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Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues

21 January 2018

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Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

21 January 2018

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The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

21 January 2018

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The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA

21 January 2018

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Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription

21 January 2018

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HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes

21 January 2018

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Activity of synthetic peptides from the Tat protein of human immunodeficiency virus type 1

21 January 2018

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The neuropathogenesis of AIDS

21 January 2018

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Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity

21 January 2018

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Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.

21 January 2018

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Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia

21 January 2018

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Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain

21 January 2018

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Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase.

21 January 2018

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HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells

21 January 2018

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HIV-1 tat transcriptional activity is regulated by acetylation

21 January 2018

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Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

21 January 2018

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Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis

21 January 2018

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Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

21 January 2018

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Establishment of a line of human fetal glial cells that supports JC virus multiplication

21 January 2018

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HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease

21 January 2018

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Potent inhibition of HIV-1 replication by a Tat mutant

21 January 2018

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Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif

21 January 2018

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Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon.

21 January 2018

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Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS.

21 January 2018

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Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.

21 January 2018

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Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine

21 January 2018

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Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort

21 January 2018

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Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): evidence for neurotropic HIV variants.

21 January 2018

1 reference

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TAR-independent activation of HIV-1 requires the activation domain but not the RNA-binding domain of Tat.

21 January 2018

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High frequency of defective vpu compared with tat and rev genes in brain from patients with HIV type 1-associated dementia.

21 January 2018

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Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.

21 January 2018

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Astrocyte specific viral strains in HIV dementia.

21 January 2018

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Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia

21 January 2018

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Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: implications for the neuropathogenesis of AIDS.

21 January 2018

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Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13365-010-0002-5

Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region.

21 January 2018

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12 December 2020

Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry

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12 December 2020

Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues

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12 December 2020

TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation

1 reference

12 December 2020

Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain.

1 reference

12 December 2020

Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta

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12 December 2020

Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity.

1 reference

12 December 2020

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

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12 December 2020

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

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12 December 2020

Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeat

1 reference

12 December 2020

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

1 reference

12 December 2020

An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

1 reference

12 December 2020

Viral phenotype and fitness.

1 reference

12 December 2020

Molecular dynamics simulations on HIV-1 Tat

1 reference

12 December 2020

Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins

1 reference

12 December 2020

Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with progressive multifocal leukoencephalopathy

1 reference

12 December 2020

Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes

1 reference

12 December 2020

Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein

1 reference

12 December 2020

Mechanisms of transcriptional transactivation and restriction of human immunodeficiency virus type I replication in an astrocytic glial cell.

1 reference

12 December 2020

Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic

1 reference

12 December 2020

Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis

1 reference

12 December 2020

Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm

1 reference

12 December 2020

A second-site mutation that restores replication of a Tat-defective human immunodeficiency virus

1 reference

12 December 2020

Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes

1 reference

12 December 2020

10.1007/S13365-010-0002-5

Identifiers

DOI

1 reference

13 September 2017

1 reference

PubMed ID

21165788