Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study (Q39625852)

13 September 2017

title

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study (English)

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13 September 2017

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ChEBI release 2020-05-28

Ya-He Liu

1

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13 September 2017

Sui-Lin Mo

2

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13 September 2017

Hui-Chang Bi

3

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13 September 2017

Bing-Fang Hu

4

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13 September 2017

Chun Guang Li

5

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13 September 2017

Yi-Tao Wang

6

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13 September 2017

Ling Huang

7

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13 September 2017

Min Huang

8

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13 September 2017

Wei Duan

9

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13 September 2017

Jun-Ping Liu

10

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13 September 2017

Ming Qian Wei

11

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13 September 2017

Shu-Feng Zhou

12

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13 September 2017

language of work or name

English

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publication date

30 November 2010

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13 September 2017

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13 September 2017

volume

41

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13 September 2017

issue

4

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13 September 2017

page(s)

259-280

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The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180.

13 September 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

PXR and the regulation of apoA1 and HDL-cholesterol in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

A pharmacophore for human pregnane X receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Herbal medicines put into context

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

21 January 2018

Herb-drug interactions

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Cytochrome P-450 3A4: regulation and role in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Herb-drug interactions: a literature review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Machine learning methods and docking for predicting human pregnane X receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Genetic predictors of interindividual variability in hepatic CYP3A4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Human Pregnane X Receptor Agonism by Ginkgo biloba Extract: Assessment of the Role of Individual Ginkgolides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Interindividual variability in inhibition and induction of cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Transcriptional regulation and expression of CYP3A4 in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Identification of a novel polymorphic enhancer of the human CYP3A4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Herbal and dietary supplement disclosure to health care providers by individuals with chronic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Clinical importance of the cytochromes P450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The structural basis of pregnane X receptor binding promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The human intestinal cytochrome P450 "pie".

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Revisiting the ancient concept of botanical therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The identification of ligand features essential for PXR activation by pharmacophore modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

CAR and PXR: the xenobiotic-sensing receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Mechanisms of cytochrome P450 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

In silico prediction of pregnane X receptor activators by machine learning approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Identification of Ginkgo biloba as a novel activator of pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

Polymorphism of human cytochrome P450 enzymes and its clinical impact

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.537395

10.3109/00498254.2010.537395

21 January 2018

Identifiers

DOI

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13 September 2017

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