Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. (Q33728760)

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English	Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.	scientific article

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scholarly article

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19 January 2020

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation (English)

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19 January 2020

colorectal cancer

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based on heuristic

inferred from title

colorectal carcinoma

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Jean Marc Pascussi

2

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19 January 2020

author name string

Caroline Raynal

1

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19 January 2020

Géraldine Leguelinel

3

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19 January 2020

Cyril Breuker

4

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19 January 2020

Jovana Kantar

5

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19 January 2020

Benjamin Lallemant

6

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19 January 2020

Sylvain Poujol

7

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19 January 2020

Caroline Bonnans

8

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19 January 2020

Dominique Joubert

9

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19 January 2020

Frédéric Hollande

10

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19 January 2020

Serge Lumbroso

11

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19 January 2020

Jean-Paul Brouillet

12

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19 January 2020

Alexandre Evrard

13

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19 January 2020

publication date

2 March 2010

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19 January 2020

Molecular Cancer

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19 January 2020

9

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19 January 2020

46

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19 January 2020

https://scigraph.springernature.com/pub.10.1186/1476-4598-9-46

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A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.

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Pregnane X receptor and its potential role in drug resistance in cancer treatment

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28 July 2018

Irinotecan toxicity

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28 July 2018

Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

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28 July 2018

The antiapoptotic role of pregnane X receptor in human colon cancer cells

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28 July 2018

Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.

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28 July 2018

Irinotecan chemotherapy during valproic acid treatment: pharmacokinetic interaction and hepatotoxicity

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28 July 2018

Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells

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28 July 2018

Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification

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Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

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"Irinogenetics" and UGT1A: from genotypes to haplotypes

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28 July 2018

ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases.

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28 July 2018

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

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28 July 2018

Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives

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28 July 2018

Induction of ABCC3 (MRP3) by pregnane X receptor activators

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28 July 2018

Lessons learned from the irinotecan metabolic pathway

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28 July 2018

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28 July 2018

PXR, CAR and drug metabolism

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28 July 2018

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

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28 July 2018

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

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28 July 2018

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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28 July 2018

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

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28 July 2018

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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28 July 2018

Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors

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28 July 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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28 July 2018

CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein

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28 July 2018

Induction of p53-independent apoptosis associated with G2M arrest following DNA damage in human colon cancer cell lines

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28 July 2018

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30 October 2018

Irinogenetics: how many stars are there in the sky?

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30 October 2018

Pharmacoecology: a new name for an old science.

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30 October 2018

Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4.

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30 October 2018

Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines

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30 October 2018

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Screening for polymorphisms in the PXR gene in a Dutch population.

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Identification of NR1I2 genetic variation using resequencing

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Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea

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12 December 2020

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CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants

1 reference

https://pubmed.ncbi.nlm.nih.gov/20196838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital

1 reference

https://pubmed.ncbi.nlm.nih.gov/20196838

12 December 2020

based on heuristic

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Adjuvant therapy for stage II and III colorectal cancer

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12 December 2020

based on heuristic

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The pregnane X receptor: from bench to bedside

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1476-4598-9-46

1 reference

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19 January 2020

Dimensions Publication ID

1 reference

https://scigraph.springernature.com/pub.10.1186/1476-4598-9-46

9 September 2019

1 reference

Europe PubMed Central

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19 January 2020

1 reference

Europe PubMed Central

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19 January 2020

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