Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen (Q39662628)

13 September 2017

Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen (English)

1 reference

13 September 2017

Benjamin W Jester

1

1 reference

13 September 2017

Alicia Gaj

2

1 reference

13 September 2017

Carolyn D Shomin

3

1 reference

13 September 2017

Kurt J Cox

4

1 reference

13 September 2017

Indraneel Ghosh

5

1 reference

13 September 2017

language of work or name

English

0 references

publication date

10 February 2012

1 reference

Journal of Medicinal Chemistry

13 September 2017

1 reference

13 September 2017

55

1 reference

13 September 2017

4

1 reference

13 September 2017

1526-1537

1 reference

describes a project that uses

13 September 2017

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

inferred from PubMed Central ID database lookup

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Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197

14 September 2017

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Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes.

14 September 2017

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A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases

14 September 2017

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Rational approaches to targeted polypharmacology: creating and navigating protein-ligand interaction networks

14 September 2017

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Apparent activity in high-throughput screening: origins of compound-dependent assay interference

14 September 2017

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Kinases as targets in the treatment of solid tumors.

14 September 2017

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Targeting the cancer kinome through polypharmacology

14 September 2017

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The nuts and bolts of AGC protein kinases

14 September 2017

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Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes

14 September 2017

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Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling

14 September 2017

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Targeting the phosphoinositide 3-kinase pathway in cancer

14 September 2017

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3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma

14 September 2017

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Characterization of chemical libraries for luciferase inhibitory activity

14 September 2017

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A quantitative analysis of kinase inhibitor selectivity

14 September 2017

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Protein kinases as small molecule inhibitor targets in inflammation.

14 September 2017

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The selectivity of protein kinase inhibitors: a further update

14 September 2017

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

14 September 2017

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The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

14 September 2017

1 reference

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The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

14 September 2017

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A small molecule-kinase interaction map for clinical kinase inhibitors

14 September 2017

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The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets

14 September 2017

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Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

14 September 2017

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A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo

14 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

14 September 2017

1 reference

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The specificities of protein kinase inhibitors: an update

14 September 2017

1 reference

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The protein kinase complement of the human genome

14 September 2017

1 reference

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4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors

14 September 2017

1 reference

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Protein kinases--the major drug targets of the twenty-first century?

14 September 2017

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Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

14 September 2017

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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

14 September 2017

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

14 September 2017

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The discovery of potent cRaf1 kinase inhibitors

14 September 2017

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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

14 September 2017

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Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

14 September 2017

1 reference

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

14 September 2017

1 reference

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Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Rottlerin, a novel protein kinase inhibitor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Aryl[ a ]pyrrolo[3,4- c ]carbazoles as selective cyclin D1-CDK4 inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

17 June 2018

Navigating the kinome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

A general and rapid cell-free approach for the interrogation of protein-protein, protein-DNA, and protein-RNA interactions and their antagonists utilizing split-protein reporters

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokin

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Inhibition of cyclin-dependent kinases by purine analogues.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328412

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

4 November 2018

1 reference

12 December 2020

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence

1 reference

12 December 2020

NGF ligand alters NGF signaling via p75(NTR) and trkA

1 reference

12 December 2020

Potent selective inhibitors of protein kinase C

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12 December 2020

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration

1 reference

12 December 2020

Structural basis for selective inhibition of Src family kinases by PP1

1 reference

12 December 2020

Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK

1 reference

12 December 2020

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution

1 reference

12 December 2020

JNK2 is a positive regulator of the cJun transcription factor

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM201265F

1 reference

13 September 2017

1 reference

13 September 2017

PubMed publication ID

22257127

1 reference