The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets (Q35666142)

9 August 2017

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title

The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets (English)

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9 August 2017

Larry W Hardy

1

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PubMed ID

14960389

9 August 2017

Norton P Peet

series ordinal

2

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9 August 2017

1 February 2004

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9 August 2017

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9 August 2017

9

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9 August 2017

3

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9 August 2017

117-126

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

9 August 2017

1 reference

7 January 2021

Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Exposing oncogenic dependencies for cancer drug target discovery and validation using RNAi

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Transgenic knockouts as part of high-throughput, evidence-based target selection and validation strategies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Chemical genetics resulting from a passion for synthetic organic chemistry.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Chemical genetics: exploring and controlling cellular processes with chemical probes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Emerging high-throughput drug target validation technologies.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

The value of improving the productivity of the drug development process: faster times and better decisions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Uteroglobin: a novel cytokine?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

The multifunctional or moonlighting protein CD26/DPPIV.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Nitric oxide, cytochrome c and mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Multifunctional proteins: examples of gene sharing

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Activating transcription factor 1 and CREB are important for cell survival during early mouse development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Adaptive immunity in mice lacking the beta(2)-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

G protein-coupled receptors: functional and mechanistic insights through altered gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Target validation of G-protein coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Isolation, characterization and targeted disruption of mouse ppia: cyclophilin A is not essential for mammalian cell viability

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Molecular mechanisms of immunosuppression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Cyclin-dependent kinases: engines, clocks, and microprocessors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Designing inhibitors of cyclin-dependent kinases

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

CDKs and CKIs: molecular targets for tissue remodelling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Proliferation of cancer cells despite CDK2 inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Reversal of activity of trimethoprim against gram-positive cocci by thymidine, thymine and 'folates'.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes

1 reference

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7 January 2021

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

1 reference

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7 January 2021

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Effects of DL-alpha-difluoromethylornithine on Leishmania donovani promastigotes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Ornithine Decarboxylase Gene Deletion Mutants ofLeishmania donovani

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

PTP1B regulates leptin signal transduction in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

A natural product that lowers cholesterol as an antagonist ligand for FXR.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

No hypothermic response to serotonin in 5-HT7 receptor knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Role of cannabinoid CB1 receptors and tumor necrosis factor-alpha in the gut and systemic anti-inflammatory activity of SR 141716 (rimonabant) in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Gut peptides and type 2 diabetes mellitus treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Dipeptidyl peptidase IV inhibition improves impaired glucose tolerance in high-fat diet-fed rats: study using a Fischer 344 rat substrain deficient in its enzyme activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Novel chemical genetic approaches to the discovery of signal transduction inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

Tools for dissecting signaling pathways in vivo: receptors activated solely by synthetic ligands.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

RASSLing with receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902969-6

7 January 2021

10.1016/S1359-6446(03)02969-6

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14960389