Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition (Q39667316)

13 September 2017

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition (English)

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13 September 2017

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5

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13 September 2017

Carmine Settembre

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Stefano Guido

Stefano Guido

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Nicola Brunetti-Pierri

Nicola Brunetti-Pierri

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Andrea Ballabio

Andrea Ballabio

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Eliezer Masliah

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Eliezer Masliah

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13 September 2017

Alessandro Luciani

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13 September 2017

Valeria Rachela Villella

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13 September 2017

Speranza Esposito

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13 September 2017

Manuela Gavina

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13 September 2017

Laura Pulze

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13 September 2017

Ida Giardino

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13 September 2017

Massimo Pettoello-Mantovani

10

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13 September 2017

Maria D'Apolito

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13 September 2017

Brian Spencer

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13 September 2017

Sonia Quaratino

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13 September 2017

Valeria Raia

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13 September 2017

Luigi Maiuri

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13 September 2017

15 August 2010

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13 September 2017

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13 September 2017

863-875

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https://scigraph.springernature.com/pub.10.1038/ncb2090

13 September 2017

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cites work

Protein aggregate characterization in models of neurodegenerative disease.

1 reference

12 December 2020

Finally, mice with CF lung disease.

1 reference

12 December 2020

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

1 reference

12 December 2020

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

1 reference

12 December 2020

The Beclin 1 interactome

1 reference

12 December 2020

Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates

1 reference

12 December 2020

Methods in mammalian autophagy research

1 reference

12 December 2020

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin

1 reference

12 December 2020

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

1 reference

12 December 2020

ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy.

1 reference

12 December 2020

CFTR and chaperones: processing and degradation.

1 reference

12 December 2020

N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells

1 reference

12 December 2020

Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice

1 reference

12 December 2020

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

1 reference

12 December 2020

The autophagy effector Beclin 1: a novel BH3-only protein

1 reference

12 December 2020

Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa.

1 reference

12 December 2020

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

1 reference

12 December 2020

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

1 reference

12 December 2020

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

12 December 2020

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

1 reference

12 December 2020

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

12 December 2020

Single-dose lentiviral gene transfer for lifetime airway gene expression

1 reference

12 December 2020

Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication

1 reference

12 December 2020

The antioxidant function of the p53 tumor suppressor

1 reference

12 December 2020

Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge

1 reference

12 December 2020

CFTR is a negative regulator of NFkappaB mediated innate immune response

1 reference

12 December 2020

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

1 reference

12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

12 December 2020

SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation.

1 reference

12 December 2020

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

1 reference

12 December 2020

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

1 reference

12 December 2020

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

1 reference

12 December 2020

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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12 December 2020

CFTR function and prospects for therapy

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12 December 2020

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway

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12 December 2020

Transglutaminases: crosslinking enzymes with pleiotropic functions

1 reference

12 December 2020

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

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12 December 2020

p62 at the crossroads of autophagy, apoptosis, and cancer

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12 December 2020

Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis

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12 December 2020

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

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12 December 2020

Cytoprotective roles for autophagy

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12 December 2020

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

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12 December 2020

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

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12 December 2020

Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking

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12 December 2020

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

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12 December 2020

Activation of the unfolded protein response by deltaF508 CFTR.

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12 December 2020

A role for ubiquitin in selective autophagy

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12 December 2020

Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation

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12 December 2020

Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy

1 reference

12 December 2020

Autophagy fights disease through cellular self-digestion

1 reference

12 December 2020

Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone

1 reference

12 December 2020

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

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12 December 2020

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12 December 2020

CFTR: new members join the fold.

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12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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12 December 2020

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

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12 December 2020

A critical role for CHIP in the aggresome pathway

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12 December 2020

Tissue transglutaminase inhibits autophagy in pancreatic cancer cells

1 reference

12 December 2020

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

1 reference

12 December 2020

Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation.

1 reference

12 December 2020

Transglutaminase is linked to neurodegenerative diseases

1 reference

12 December 2020

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

1 reference

12 December 2020

Autophagy suppresses tumorigenesis through elimination of p62

1 reference

12 December 2020

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

1 reference

12 December 2020

Self-eating and self-killing: crosstalk between autophagy and apoptosis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCB2090

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release_oxdokcv52jdrvcl3phi5n7zhny

13 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/oxdokcv52jdrvcl3phi5n7zhny

24 November 2022

mapped directly with Wikidata item

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