Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives (Q39667620)

13 September 2017

Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives (English)

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13 September 2017

Robert P Sellers

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13 September 2017

Leslie D Alexander

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13 September 2017

Victoria A Johnson

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13 September 2017

Chun-Chieh Lin

4

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13 September 2017

Jeremiah Savage

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13 September 2017

Ricardo Corral

6

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13 September 2017

Jason Moss

7

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13 September 2017

Tim S Slugocki

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13 September 2017

Erinprit K Singh

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13 September 2017

Melinda R Davis

10

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13 September 2017

Suchitra Ravula

11

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13 September 2017

Jamie E Spicer

12

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13 September 2017

Jenna L Oelrich

13

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13 September 2017

Andrea Thornquist

14

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13 September 2017

Chung-Mao Pan

15

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13 September 2017

Shelli R McAlpine

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13 September 2017

language of work or name

English

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publication date

22 July 2010

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Bioorganic & Medicinal Chemistry

13 September 2017

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18

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18

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13 September 2017

6822-6856

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describes a project that uses

13 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2933939/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Aplidine: a paradigm of how to handle the activity and toxicity of a novel marine anticancer poison

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Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Rapid, high-yield, solid-phase synthesis of the antitumor antibiotic sansalvamide A using a side-chain-tethered phenylalanine building block

14 September 2017

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Mechanism of inhibition of a poxvirus topoisomerase by the marine natural product sansalvamide A.

14 September 2017

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

14 September 2017

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Mechanism of Dimer Formation of the 90‐kDa Heat‐Shock Protein

14 September 2017

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Liver transplantation with use of cyclosporin a and prednisone

14 September 2017

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A comprehensive study of Sansalvamide A derivatives: The structure-activity relationships of 78 derivatives in two pancreatic cancer cell lines

14 September 2017

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Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines.

14 September 2017

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Identification of Sansalvamide a analog potent against pancreatic cancer cell lines

14 September 2017

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Scaffold targeting drug-resistant colon cancers

14 September 2017

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The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.

14 September 2017

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Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29.

14 September 2017

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14 September 2017

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Synthesis and novel structure-activity relationships of potent sansalvamide A derivatives

14 September 2017

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14 September 2017

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A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

14 September 2017

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Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines

14 September 2017

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Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells

14 September 2017

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ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition

14 September 2017

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N-methylsansalvamide a peptide analogues. Potent new antitumor agents

14 September 2017

1 reference

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In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative

14 September 2017

1 reference

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Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro

14 September 2017

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Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C.

14 September 2017

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Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

14 September 2017

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N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus fusarium.

14 September 2017

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Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.

25 September 2017

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Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides

17 June 2018

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Heat shock proteins are differentially expressed in human gastrointestinal cancers.

17 June 2018

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Modeling of peptides containing D-amino acids: implications on cyclization.

17 June 2018

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Using AutoDock for ligand-receptor docking

21 August 2018

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Synthesis of second-generation sansalvamide A derivatives: novel templates as potential antitumor agents.

21 August 2018

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Phase I study of Aplidine in a dailyx5 one-hour infusion every 3 weeks in patients with solid tumors refractory to standard therapy. A National Cancer Institute of Canada Clinical Trials Group study: NCIC CTG IND 115.

21 August 2018

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Bio3d: an R package for the comparative analysis of protein structures.

21 August 2018

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17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway

21 August 2018

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Phase I and pharmacokinetic study of aplidine, a new marine cyclodepsipeptide in patients with advanced malignancies.

21 August 2018

1 reference

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NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol

21 August 2018

1 reference

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17AAG: low target binding affinity and potent cell activity--finding an explanation

21 August 2018

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The Conformation ofcyclo(−d-Pro−Ala4−) as a Model for Cyclic Pentapeptides of thedL4Type

21 August 2018

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Radester, a novel inhibitor of the Hsp90 protein folding machinery

2 December 2018

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12 December 2020

Synthesis and cytotoxicity of novel sansalvamide A derivatives

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12 December 2020

Solid-phase, Pd-catalyzed silicon-aryl carbon bond formation. Synthesis of sansalvamide A peptide

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12 December 2020

Monomer arrangement in HSP90 dimer as determined by decoration with N and C-terminal region specific antibodies

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12 December 2020

10.1016/J.BMC.2010.07.042

Identifiers

DOI

1 reference

13 September 2017

1 reference

13 September 2017

PubMed publication ID

20708938

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