The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells. (Q40213329)

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21 December 2019

title

The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells (English)

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21 December 2019

1

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21 December 2019

Harikrishna Nakshatri

5

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21 December 2019

author name string

Minati Satpathy

2

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21 December 2019

Liyun Cao

3

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21 December 2019

Yi-Chun Lai

4

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21 December 2019

David B Donner

6

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21 December 2019

language of work or name

English

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publication date

1 November 2006

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Journal of Biological Chemistry

21 December 2019

published in

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21 December 2019

volume

282

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21 December 2019

issue

1

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21 December 2019

page(s)

445-453

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Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

21 December 2019

cites work

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

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Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

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Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.

21 January 2018

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Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

21 January 2018

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Isolation of Hsp90 mutants by screening for decreased steroid receptor function

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Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

21 January 2018

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Reduced levels of hsp90 compromise steroid receptor action in vivo

21 January 2018

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

21 January 2018

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Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

21 January 2018

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

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Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

21 January 2018

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

21 January 2018

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Hsp90 chaperones protein folding in vitro.

21 January 2018

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HSP90 and the chaperoning of cancer

21 January 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

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Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

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Molecular and cytogenetic analysis of glioblastoma multiforme.

21 January 2018

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PDGFRA activating mutations in gastrointestinal stromal tumors.

21 January 2018

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Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

21 January 2018

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Expression of c-ABL, c-KIT, and platelet-derived growth factor receptor-beta in ovarian serous carcinoma and normal ovarian surface epithelium

21 January 2018

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Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and Akt inactivation

21 January 2018

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Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer.

21 January 2018

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Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes

21 January 2018

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Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

21 January 2018

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Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration

21 January 2018

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Effect of imatinib mesylate on neuroblastoma tumorigenesis and vascular endothelial growth factor expression

21 January 2018

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R-Ras is regulated by activators and effectors distinct from those that control Ras function

21 January 2018

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Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress

21 January 2018

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21 January 2018

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21 January 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

21 January 2018

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Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.

21 January 2018

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Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases

21 January 2018

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Platelet-derived growth factor in human glioma

21 January 2018

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Distinct monoubiquitin signals in receptor endocytosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M607012200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17079230%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference