Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway (Q39680723)

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scientific article published on 15 May 2008

Language	Label	Description	Also known as
English	Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway	scientific article published on 15 May 2008

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway (English)

1 reference

Europe PubMed Central

13 September 2017

3

1 reference

Europe PubMed Central

13 September 2017

Maria Trojanowska

4

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Europe PubMed Central

13 September 2017

author name string

Shizhong Bu

1

1 reference

Europe PubMed Central

13 September 2017

Bagrat Kapanadze

2

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Europe PubMed Central

13 September 2017

language of work or name

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publication date

15 May 2008

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Europe PubMed Central

13 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

13 September 2017

283

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Europe PubMed Central

13 September 2017

28

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Europe PubMed Central

13 September 2017

19593-19602

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Europe PubMed Central

13 September 2017

Transforming growth factor-beta and fibrosis

1 reference

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Essential role for nuclear PTEN in maintaining chromosomal integrity

1 reference

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Ubiquitination regulates PTEN nuclear import and tumor suppression

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Functions of the multifaceted family of sphingosine kinases and some close relatives

1 reference

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Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs

1 reference

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Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN

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PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

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PTEN as an effector in the signaling of antimigratory G protein-coupled receptor

1 reference

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Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

1 reference

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The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

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Biologically active sphingolipids in cancer pathogenesis and treatment

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PTEN function: how normal cells control it and tumour cells lose it

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Point-counterpoint of sphingosine 1-phosphate metabolism

1 reference

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

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Discovery and evaluation of inhibitors of human sphingosine kinase

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Sphingosine-1-phosphate: an enigmatic signalling lipid

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PTEN and myotubularin: novel phosphoinositide phosphatases

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The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

1 reference

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Phosphorylation of the PTEN tail regulates protein stability and function

1 reference

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TGF-beta signal transduction

1 reference

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Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

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Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival

1 reference

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Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1.

1 reference

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Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein

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Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity

1 reference

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PTEN enters the nucleus by diffusion

1 reference

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An oncogenic role of sphingosine kinase

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De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells

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Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge

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1 reference

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1 reference

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Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses

1 reference

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1 reference

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PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M802417200

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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