Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (Q39681091)

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scientific article published on 30 November 2007

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English	Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.	scientific article published on 30 November 2007

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29 December 2019

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia (English)

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29 December 2019

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29 December 2019

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Anuradha Dhanasekaran

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29 December 2019

Stephanie K Gruenloh

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29 December 2019

J Noelle Buonaccorsi

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29 December 2019

Rong Zhang

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29 December 2019

Garrett J Gross

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29 December 2019

Paresh K Patel

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29 December 2019

Elizabeth R Jacobs

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29 December 2019

Meetha Medhora

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29 December 2019

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30 November 2007

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29 December 2019

American Journal of Physiology Heart and Circulatory Physiology

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29 December 2019

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29 December 2019

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29 December 2019

H724-35

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29 December 2019

Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways.

1 reference

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14 September 2017

Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts

1 reference

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14 September 2017

Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

14 September 2017

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

1 reference

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14 September 2017

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function

1 reference

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14 September 2017

Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury

1 reference

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14 September 2017

The survival kinases Akt and Pim as potential pharmacological targets

1 reference

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14 September 2017

Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors

1 reference

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14 September 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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14 September 2017

Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt.

1 reference

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14 September 2017

The mitochondrial death pathway and cardiac myocyte apoptosis

1 reference

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14 September 2017

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

1 reference

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14 September 2017

PI 3-kinase, Akt and cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

14 September 2017

A mechanistic role for cardiac myocyte apoptosis in heart failure

1 reference

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14 September 2017

HETEs/EETs in renal glomerular and epithelial cell functions

1 reference

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14 September 2017

Mechanism of XIAP-mediated inhibition of caspase-9

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14 September 2017

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

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14 September 2017

P-450 metabolites of arachidonic acid in the control of cardiovascular function

1 reference

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14 September 2017

Cytochrome p450 and vascular homeostasis

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14 September 2017

EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes

1 reference

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14 September 2017

Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

14 September 2017

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

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14 September 2017

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

1 reference

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14 September 2017

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

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14 September 2017

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1 reference

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14 September 2017

HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

1 reference

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14 September 2017

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

14 September 2017

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

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14 September 2017

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

1 reference

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14 September 2017

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

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14 September 2017

14-3-3: modulators of signaling proteins?

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14 September 2017

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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14 September 2017

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

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14 September 2017

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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14 September 2017

Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).

1 reference

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14 September 2017

Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

1 reference

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14 September 2017

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53

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14 September 2017

14-3-3 proteins. Hot numbers in signal transduction

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14 September 2017

Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids

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25 September 2017

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

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25 September 2017

Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries.

1 reference

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25 September 2017

Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes

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25 September 2017

Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells

1 reference

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25 September 2017

Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

25 September 2017

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

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25 September 2017

The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

15 June 2018

Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation.

1 reference

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15 June 2018

Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite

1 reference

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15 June 2018

Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

21 August 2018

Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

21 August 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

21 August 2018

The nitric oxide- and prostaglandin-independent component of the renal vasodilator effect of thimerosal is mediated by epoxyeicosatrienoic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

21 August 2018

Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2443685

21 August 2018

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1 reference

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21 August 2018

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21 August 2018

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21 August 2018

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1 reference

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21 August 2018

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21 August 2018

14(R),15(S)-epoxyeicosatrienoic acid (14(R),15(S)-EET) receptor in guinea pig mononuclear cell membranes.

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21 August 2018

Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats

1 reference

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12 December 2020

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Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in ischemic and reperfused rat myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis meets signal transduction: elimination of a BAD influence

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in the failing human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocyte death in the failing human heart is gender dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18055514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPHEART.00979.2007

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Europe PubMed Central

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29 December 2019

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Europe PubMed Central

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29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

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29 December 2019

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