1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells (Q39687652)

14 September 2017

1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells (English)

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14 September 2017

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Linara S Axanova

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14 September 2017

Yong Q Chen

2

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14 September 2017

Thomas McCoy

3

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14 September 2017

Guangchao Sui

4

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14 September 2017

Scott D Cramer

5

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1 November 2010

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70

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15

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1658-1671

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describes a project that uses

14 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3039487/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression

14 September 2017

1 reference

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Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery

14 September 2017

1 reference

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Characterization of adult prostatic progenitor/stem cells exhibiting self-renewal and multilineage differentiation

14 September 2017

1 reference

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Cellular senescence: when bad things happen to good cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Inhibition of Akt pathways in the treatment of prostate cancer

14 September 2017

1 reference

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Calcitriol in the treatment of prostate cancer

14 September 2017

1 reference

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

14 September 2017

1 reference

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

14 September 2017

1 reference

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Expression signature of the mouse prostate

14 September 2017

1 reference

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Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization

14 September 2017

1 reference

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The emerging role of the PI3-K-Akt pathway in prostate cancer progression

14 September 2017

1 reference

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A system for studying epithelial-stromal interactions reveals distinct inductive abilities of stromal cells from benign prostatic hyperplasia and prostate cancer

14 September 2017

1 reference

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The biology and clinical relevance of the PTEN tumor suppressor pathway

14 September 2017

1 reference

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

14 September 2017

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Antiproliferative role of vitamin D and its analogs--a brief overview

14 September 2017

1 reference

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Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression

14 September 2017

1 reference

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo

14 September 2017

1 reference

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Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence

14 September 2017

1 reference

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1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell growth by androgen-dependent and androgen-independent mechanisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Vitamin D and prostate cancer

14 September 2017

1 reference

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Direct control of the Forkhead transcription factor AFX by protein kinase B

14 September 2017

1 reference

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

14 September 2017

1 reference

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

14 September 2017

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

14 September 2017

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

14 September 2017

1 reference

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Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Vitamin D receptor content and transcriptional activity do not fully predict antiproliferative effects of vitamin D in human prostate cancer cell lines

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis).

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Tumour biology: senescence in premalignant tumours

15 June 2018

1 reference

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Culture of mouse prostatic epithelial cells from genetically engineered mice

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

A negative feedback signaling network underlies oncogene-induced senescence

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Calcitriol (1,25-dihydroxycholecalciferol) potentiates activity of mitoxantrone/dexamethasone in an androgen independent prostate cancer model

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039487

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

20 August 2018

1 reference

12 December 2020

Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland)

1 reference

12 December 2020

Vitamin D inhibition of prostate adenocarcinoma growth and metastasis in the Dunning rat prostate model system

1 reference

12 December 2020

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

12 December 2020

Genistein and vitamin D synergistically inhibit human prostatic epithelial cell growth

1 reference

12 December 2020

BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells

1 reference

12 December 2020

Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators

1 reference

12 December 2020

Posttranscriptional induction of p21Waf1 mediated by ectopic p16INK4 in human diploid fibroblast

1 reference

12 December 2020

10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer

1 reference

12 December 2020

Identifiers

DOI

10.1002/PROS.21201

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14 September 2017

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14 September 2017

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