Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration (Q39702852)

14 September 2017

Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration (English)

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14 September 2017

Amel Dudakovic

1

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PubMed ID

20480384

14 September 2017

Huaxiang Tong

series ordinal

2

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PubMed ID

20480384

14 September 2017

Raymond J Hohl

series ordinal

3

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14 September 2017

18 May 2010

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Investigational New Drugs

14 September 2017

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14 September 2017

29

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14 September 2017

5

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14 September 2017

912-920

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https://scigraph.springernature.com/pub.10.1007/s10637-010-9446-y

14 September 2017

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cites work

HMG-CoA reductase inhibitors for treatment of hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Isoprenoids: remarkable diversity of form and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Discovery, clinical development, and therapeutic uses of bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

The Ras superfamily at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Targeting RAS signalling pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

21 January 2018

RHO-GTPases and cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Anti-cancer therapy: targeting the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

The intermediate enzymes of isoprenoid metabolism as anticancer targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Synthesis and biological activity of isoprenoid bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Role of Rho GTPases in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Rho GTPases are over-expressed in human tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

The large-scale digital cell analysis system: an open system for nonperturbing live cell imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Poly(ADP-ribose): novel functions for an old molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Quantitative determination of geranyl diphosphate levels in cultured human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Geranylgeranylation but not GTP loading determines rho migratory function in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9446-Y

Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes

21 January 2018

1 reference

12 December 2020

Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.

1 reference

12 December 2020

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

12 December 2020

Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.

1 reference

12 December 2020

Cell segmentation, tracking, and mitosis detection using temporal context

1 reference

12 December 2020

10.1007/S10637-010-9446-Y

Identifiers

DOI

1 reference

14 September 2017

1 reference

PubMed ID

20480384