Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets. (Q39797821)

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7 February 2020

title

Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets (English)

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7 February 2020

5

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7 February 2020

author name string

Marina Casimir

1

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7 February 2020

Blanca Rubi

2

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7 February 2020

Francesca Frigerio

3

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7 February 2020

Gaelle Chaffard

4

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7 February 2020

language of work or name

English

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publication date

10 December 2009

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7 February 2020

number of pages

8

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based on heuristic

inferred from page(s)

published in

Biochemical Journal

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7 February 2020

volume

424

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7 February 2020

issue

3

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7 February 2020

page(s)

459-466

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Molecular physiology of mammalian glucokinase

7 February 2020

cites work

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K(ATP) channels and insulin secretion: a key role in health and disease

21 January 2018

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Novel aspects of the molecular mechanisms controlling insulin secretion

21 January 2018

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

21 January 2018

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In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion

21 January 2018

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Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain

21 January 2018

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Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

21 January 2018

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Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria

21 January 2018

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The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

21 January 2018

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Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

21 January 2018

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Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier

21 January 2018

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NADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretion

21 January 2018

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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

21 January 2018

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Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

21 January 2018

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GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090729

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090729

Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion

21 January 2018

1 reference

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Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion

21 January 2018

1 reference

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Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090729

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

21 January 2018

1 reference

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Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis

21 January 2018

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Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.

21 January 2018

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Mitochondrial activation and the pyruvate paradox in a human cell line.

21 January 2018

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A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090729

Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090729

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090729

21 January 2018

Identifiers

DOI

10.1042/BJ20090729

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19764902%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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