FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway (Q39817169)

14 September 2017

FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway (English)

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14 September 2017

Wenchao Zhou

1

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14 September 2017

Xiujing Feng

2

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14 September 2017

Yingjie Wu

3

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14 September 2017

Johannes Benge

4

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14 September 2017

Zhe Zhang

5

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14 September 2017

Zhengjun Chen

6

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14 September 2017

4 August 2009

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14 September 2017

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14 September 2017

19

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14 September 2017

10

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14 September 2017

1165-1177

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https://scigraph.springernature.com/pub.10.1038/cr.2009.95

14 September 2017

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Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

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FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

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Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

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FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors

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Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling

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Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

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FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

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Dockers at the crossroads

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The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

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EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

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The MAPK signaling cascade

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

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Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

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Docking interactions induce exposure of activation loop in the MAP kinase ERK2

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.

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Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes

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Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

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Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

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Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.

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Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2.

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7 January 2021

Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells

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7 January 2021

Identifiers

DOI

10.1038/CR.2009.95

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14 September 2017

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