FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway (Q39817169)

14 September 2017

title

FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway (English)

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14 September 2017

Wenchao Zhou

1

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14 September 2017

Xiujing Feng

2

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14 September 2017

Yingjie Wu

3

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14 September 2017

Johannes Benge

4

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14 September 2017

Zhe Zhang

5

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14 September 2017

Zhengjun Chen

6

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14 September 2017

publication date

4 August 2009

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14 September 2017

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14 September 2017

volume

19

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14 September 2017

issue

10

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14 September 2017

page(s)

1165-1177

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

14 September 2017

cites work

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7 January 2021

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

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7 January 2021

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

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7 January 2021

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

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7 January 2021

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

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7 January 2021

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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7 January 2021

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

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7 January 2021

FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors

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7 January 2021

Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling

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7 January 2021

Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

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7 January 2021

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

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7 January 2021

Dockers at the crossroads

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7 January 2021

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

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7 January 2021

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

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7 January 2021

Environmental-dependent acceleration of a developmental switch: the floral transition

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7 January 2021

Mammalian MAP kinase signalling cascades

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7 January 2021

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

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7 January 2021

Signaling networks--do all roads lead to the same genes?

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7 January 2021

Cell signaling by receptor tyrosine kinases

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7 January 2021

Signaling pathways for PC12 cell differentiation: making the right connections

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7 January 2021

The MAPK signaling cascade

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7 January 2021

A conserved docking motif in MAP kinases common to substrates, activators and regulators

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7 January 2021

Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues

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7 January 2021

SNT, a Differentiation-Specific Target of Neurotrophic Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 Cells

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7 January 2021

SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.

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7 January 2021

Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways

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7 January 2021

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

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https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Docking interactions induce exposure of activation loop in the MAP kinase ERK2

1 reference

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7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.

1 reference

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7 January 2021

Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

1 reference

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7 January 2021

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

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https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Fibroblast growth factors and their receptors in the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.95

7 January 2021

Identifiers

DOI

10.1038/CR.2009.95

1 reference

14 September 2017

1 reference