Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis (Q24337862)

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English	Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis	scientific article

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scholarly article

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28 January 2020

Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis (English)

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28 January 2020

apoptotic process

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oligodendrocyte apoptotic process

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

Growth arrest specific 6

1 reference

GOA release 2020-03-11

tumor necrosis factor

1 reference

GOA release 2020-03-11

negative regulation of oligodendrocyte apoptotic process

1 reference

GOA release 2020-03-11

Growth arrest specific 6

1 reference

GOA release 2020-03-11

AXL receptor tyrosine kinase

1 reference

GOA release 2020-03-11

oligodendrocyte

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based on heuristic

inferred from title

Celia F. Brosnan

6

object named as

Celia F Brosnan

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28 January 2020

author name string

Sai Latha Shankar

1

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28 January 2020

Kathleen O'Guin

2

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Mimi Kim

3

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28 January 2020

Brian Varnum

4

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28 January 2020

Greg Lemke

5

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28 January 2020

Bridget Shafit-Zagardo

7

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language of work or name

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publication date

1 May 2006

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28 January 2020

Journal of Neuroscience

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26

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21

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5638-5648

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28 January 2020

describes a project that uses

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based on heuristic

inferred from PubMed Central ID database lookup

Isolation and characterization of immature oligodendrocyte lineage cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular survival: a play in three Akts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour necrosis factor alpha mRNA expression in early multiple sclerosis lesions: correlation with demyelinating activity and oligodendrocyte pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: role of ceramide in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve Growth Factor Protects Oligodendrocytes from Tumor Necrosis Factor-α-induced Injury through Akt-mediated Signaling Mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fyn tyrosine kinase regulates oligodendroglial cell development but is not required for morphological differentiation of oligodendrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cultured oligodendrocytes mimic in vivo phenotypic characteristics: cell shape, expression of myelin-specific antigens, and membrane production

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP regulates the rate of differentiation of oligodendrocytes without changing the lineage commitment of their progenitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple and novel specificities of monoclonal antibodies O1, O4, and R-mAb used in the analysis of oligodendrocyte development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligodendrocyte progenitors isolated directly from developing telencephalon at a specific phenotypic stage: myelinogenic potential in a defined environment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor tyrosine kinases and their targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Gas6 as a growth factor for human Schwann cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor selectively protects human oligodendrocytes from tumor necrosis factor-mediated injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of immune injury in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K: downstream AKTion blocks apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the control of cell growth; the role of the AxI family

1 reference

https://pubmed.ncbi.nlm.nih.gov/16723520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5063-05.2006

1 reference

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28 January 2020

1 reference

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28 January 2020

1 reference

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28 January 2020

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