Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects (Q39821613)

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English	Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects	scientific article

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scholarly article

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Europe PubMed Central

14 September 2017

Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects (English)

1 reference

Europe PubMed Central

14 September 2017

author name string

M C Rauch

1

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Europe PubMed Central

14 September 2017

A San Martín

2

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Europe PubMed Central

14 September 2017

D Ojeda

3

1 reference

Europe PubMed Central

14 September 2017

C Quezada

4

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Europe PubMed Central

14 September 2017

M Salas

5

1 reference

Europe PubMed Central

14 September 2017

J G Cárcamo

6

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Europe PubMed Central

14 September 2017

A J Yañez

7

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Europe PubMed Central

14 September 2017

J C Slebe

8

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Europe PubMed Central

14 September 2017

A Claude

9

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Europe PubMed Central

14 September 2017

publication date

21 July 2009

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Europe PubMed Central

14 September 2017

Transplant Immunology

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Europe PubMed Central

14 September 2017

22

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Europe PubMed Central

14 September 2017

1-2

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Europe PubMed Central

14 September 2017

72-81

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Europe PubMed Central

14 September 2017

Efficacy and safety of tacrolimus in patients with rheumatoid arthritis: a double-blind trial

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Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis

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Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules

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A review of the action of tacrolimus (FK506) on experimental models of rheumatoid arthritis

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Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

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Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12

1 reference

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

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Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506.

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FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line

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Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation

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Neurotoxicity in liver transplant recipients with cyclosporine immunosuppression

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Oral cyclosporine decreases severity of neurotoxicity in liver transplant recipients

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Conversion to neoral for neurotoxicity after primary adult liver transplantation under tacrolimus

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Post-transplant diabetes mellitus: increasing incidence in renal allograft recipients transplanted in recent years

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A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group

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Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channel

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Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets

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Rapamycin Has a Deleterious Effect on MIN-6 Cells and Rat and Human Islets

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Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells

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Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

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Recovery from diabetes in mice by beta cell regeneration

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Morphological and functional changes of islets of Langerhans in FK506-treated rats

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Mechanism of FK506-induced glucose intolerance in rats

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Effect of FK506 on insulin secretion in normal dogs

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FK506-induced impairment of glucose metabolism in the primate--studies in pancreatic transplant recipients and in nontransplanted animals.

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Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats.

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Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy

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Biotin supply affects expression of biotin transporters, biotinylation of carboxylases and metabolism of interleukin-2 in Jurkat cells

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Uptake and metabolism of biotin by human peripheral blood mononuclear cells

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Differential signalling for enhanced hexose uptake by interleukin (IL)-3 and IL-5 in male germ cells

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Oxidative folding of interleukin-2 is impaired in flavin-deficient jurkat cells, causing intracellular accumulation of interleukin-2 and increased expression of stress response genes.

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Induction of human T colony formation by phorbol myristate acetate

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Specific receptors for phorbol esters in lymphoid cell populations: role in enhanced production of T-cell growth factor

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Cloning of the gamma chain of the human IL-2 receptor

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Brefeldin A: insights into the control of membrane traffic and organelle structure

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p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A

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Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

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Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

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Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

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Insulin secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines

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Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch.

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Antiinflammatory effects of Tacrolimus in a mouse model of pleurisy.

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Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

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Relative risk of new-onset diabetes during the first year after renal transplantation in patients receiving tacrolimus or cyclosporine immunosuppression.

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Development of insulin resistance and elevated blood pressure during therapy with cyclosporine A

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Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB.

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Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells

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Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.

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Effects of non-steroid immunosuppressive drugs on insulin secretion in transplantation.

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Tacrolimus-Induced Diabetes in Rats Courses with Suppressed Insulin Gene Expression in Pancreatic Islets

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Pancreatic and nephrotoxicity of immunomodulator compounds

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Calcineurin nephrotoxicity

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Chronic cyclosporine nephropathy: the Achilles' heel of immunosuppressive therapy

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Cyclosporine-associated chronic nephropathy

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Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis

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Expression of apoptosis-related genes in chronic cyclosporine nephrotoxicity in mice

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Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis

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Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis

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Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation

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GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic

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Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1

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Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively

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Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity

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10.1016/J.TRIM.2009.07.001

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Europe PubMed Central

14 September 2017

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Europe PubMed Central

14 September 2017

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