Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate (Q39833736)

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11 March 2020

title

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate (English)

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11 March 2020

6

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John Schwabe

7

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11 March 2020

author name string

Michelle A Hughes

1

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11 March 2020

Ian R Powley

2

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11 March 2020

Rebekah Jukes-Jones

3

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11 March 2020

Sebastian Horn

4

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Maria Feoktistova

5

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11 March 2020

Martin Leverkus

8

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Kelvin Cain

9

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Marion MacFarlane

10

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publication date

1 March 2016

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11 March 2020

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11 March 2020

volume

61

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11 March 2020

issue

6

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11 March 2020

page(s)

834-849

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The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments

11 March 2020

cites work

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Crystal structure of the death effector domains of caspase-8

22 September 2017

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The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival

22 September 2017

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Isolation, characterisation and reconstitution of cell death signalling complexes

22 September 2017

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A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death

22 September 2017

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Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model

22 September 2017

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Survival function of the FADD-CASPASE-8-cFLIP(L) complex

22 September 2017

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The 'complexities' of life and death: death receptor signalling platforms

22 September 2017

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Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions

22 September 2017

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Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis

22 September 2017

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Many stimuli pull the necrotic trigger, an overview

22 September 2017

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

22 September 2017

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

22 September 2017

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Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex

22 September 2017

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

22 September 2017

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

22 September 2017

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FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

22 September 2017

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The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

22 September 2017

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Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

22 September 2017

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Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

22 September 2017

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Mechanism of procaspase-8 activation by c-FLIPL

22 September 2017

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Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation

22 September 2017

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The Fas-FADD death domain complex structure unravels signalling by receptor clustering

22 September 2017

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c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival

22 September 2017

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Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

22 September 2017

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Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition

22 September 2017

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22 September 2017

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

22 September 2017

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Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis

22 September 2017

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The role of c-FLIP in modulation of CD95-induced apoptosis

22 September 2017

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Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis

22 September 2017

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Inhibition of death receptor signals by cellular FLIP

22 September 2017

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22 September 2017

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Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

22 September 2017

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Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

22 September 2017

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

15 June 2018

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Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

15 June 2018

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Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis

20 August 2018

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Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

20 August 2018

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Solution NMR Investigation of the CD95/FADD Homotypic Death Domain Complex Suggests Lack of Engagement of the CD95 C Terminus

20 August 2018

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10.1016/J.MOLCEL.2016.02.023

2 December 2018

Identifiers

DOI

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release_oui6orvk6nby5fiyo4hpqzbyw4

11 March 2020

Fatcat ID

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mapped directly with Wikidata item

24 November 2022

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PubMed publication ID

26990987

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