RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. (Q39843528)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20026589%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha (English)

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15 January 2020

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4

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15 January 2020

author name string

Martijn van Hagen

series ordinal

1

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15 January 2020

René M Overmeer

series ordinal

2

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15 January 2020

Sharareh S Abolvardi

series ordinal

3

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15 January 2020

publication date

21 December 2009

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15 January 2020

published in

Nucleic Acids Research

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15 January 2020

volume

38

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15 January 2020

issue

6

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15 January 2020

page(s)

1922-1931

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15 January 2020

1 reference

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Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3.

22 September 2017

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

22 September 2017

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

22 September 2017

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Concepts in sumoylation: a decade on

22 September 2017

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SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

22 September 2017

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RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

22 September 2017

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SUMO-targeted ubiquitin ligases in genome stability.

22 September 2017

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Hypoxia inducible factor-2alpha in cancer.

22 September 2017

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Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice

22 September 2017

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Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics

22 September 2017

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Something about SUMO inhibits transcription

22 September 2017

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Negative and positive regulation of HIF-1: a complex network

22 September 2017

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Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

22 September 2017

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SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

22 September 2017

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The HIF pathway as a therapeutic target

22 September 2017

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Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo

22 September 2017

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A proteomic study of SUMO-2 target proteins

22 September 2017

1 reference

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Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions

22 September 2017

1 reference

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Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

22 September 2017

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

22 September 2017

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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

22 September 2017

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

22 September 2017

1 reference

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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex

22 September 2017

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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22 September 2017

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Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

22 September 2017

1 reference

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Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins

25 September 2017

1 reference

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The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle

17 June 2018

1 reference

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20 August 2018

1 reference

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SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity.

20 August 2018

1 reference

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Detection of modification by ubiquitin-like proteins

20 August 2018

1 reference

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Sumoylation increases HIF-1alpha stability and its transcriptional activity

20 August 2018

1 reference

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SUMO promotes HDAC-mediated transcriptional repression

20 August 2018

1 reference

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The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20026589

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nuclear localization of hypoxia-inducible factor-2alpha in bovine arterial endothelial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20026589

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p300 Transcriptional Repression Is Mediated by SUMO Modification

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20026589

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKP1157

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20026589%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20026589%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

20026589

1 reference