Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent (Q39914977)

15 September 2017

title

Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent (English)

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15 September 2017

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Christian Rust

1

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15 September 2017

Nadine Wild

2

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15 September 2017

Carina Bernt

3

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15 September 2017

Timo Vennegeerts

4

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15 September 2017

Ralf Wimmer

5

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15 September 2017

Ulrich Beuers

6

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15 September 2017

language of work or name

English

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publication date

18 November 2008

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Journal of Biological Chemistry

15 September 2017

published in

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15 September 2017

volume

284

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15 September 2017

issue

5

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15 September 2017

page(s)

2908-2916

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Cholestatic liver disease: pathophysiology and therapeutic options

15 September 2017

cites work

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A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation

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Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation

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Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis.

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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

21 January 2018

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Bile salt-induced apoptosis involves NADPH oxidase isoform activation

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The CD95 type I/type II model

21 January 2018

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Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.

21 January 2018

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Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids

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Caspases: the executioners of apoptosis

21 January 2018

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Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

21 January 2018

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Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells

21 January 2018

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The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis

21 January 2018

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An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

21 January 2018

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The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade

21 January 2018

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Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers

21 January 2018

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Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.

21 January 2018

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The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.

21 January 2018

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Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells

21 January 2018

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Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis

21 January 2018

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

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The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95.

21 January 2018

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Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas.

21 January 2018

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Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation

21 January 2018

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Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

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Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M804585200

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15 September 2017

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