BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis. (Q39920726)

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25 December 2019

title

BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis (English)

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25 December 2019

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7

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25 December 2019

author name string

Leslie A Miller

1

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25 December 2019

Nathaniel B Goldstein

2

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25 December 2019

Widya U Johannes

3

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25 December 2019

Christine H Walton

4

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25 December 2019

Mayumi Fujita

5

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25 December 2019

David A Norris

6

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25 December 2019

language of work or name

English

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publication date

6 November 2008

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Journal of Investigative Dermatology

25 December 2019

published in

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volume

129

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25 December 2019

issue

4

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25 December 2019

page(s)

964-971

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https://scigraph.springernature.com/pub.10.1038/jid.2008.327

25 December 2019

exact match

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cites work

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members.

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

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Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells

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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

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Cutaneous Malignant Melanoma

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Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications.

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Chemotherapy for metastatic melanoma: time for a change?

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Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

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BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts.

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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BCL-2: found bound and drugged!

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Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

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Conformation of the Bax C-terminus regulates subcellular location and cell death

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA.

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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

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RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway.

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Lovastatin-induced apoptosis in human melanoma cell lines

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7 January 2021

A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

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7 January 2021

Apoptosis and melanoma chemoresistance

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7 January 2021

BCL2 family of apoptosis-related genes: functions and clinical implications in cancer

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

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7 January 2021

Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins

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7 January 2021

Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis

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7 January 2021

Identifiers

DOI

10.1038/JID.2008.327

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18987671%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference