MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells (Q39938190)

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scientific article published on 16 April 2008

Language	Label	Description	Also known as
English	MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells	scientific article published on 16 April 2008

Statements

scholarly article

1 reference

Europe PubMed Central

15 September 2017

MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells (English)

1 reference

Europe PubMed Central

15 September 2017

author name string

Dariush Mokhtari

1

1 reference

Europe PubMed Central

15 September 2017

Jason W Myers

2

1 reference

Europe PubMed Central

15 September 2017

Nils Welsh

3

1 reference

Europe PubMed Central

15 September 2017

language of work or name

0 references

publication date

16 April 2008

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

57

1 reference

Europe PubMed Central

15 September 2017

7

1 reference

Europe PubMed Central

15 September 2017

1896-1904

1 reference

Europe PubMed Central

15 September 2017

Lipofection of insulin-producing RINm5F cells: methodological improvements

1 reference

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22 September 2017

Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453607

22 September 2017

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

1 reference

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22 September 2017

Role of MKK3 and p38 MAPK in cytokine-induced death of insulin-producing cells

1 reference

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22 September 2017

siRNA produced by recombinant dicer mediates efficient gene silencing in islet cells

1 reference

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22 September 2017

Mechanisms of type-I- and type-II-interferon-mediated signalling

1 reference

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22 September 2017

Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation

1 reference

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22 September 2017

Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families

1 reference

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Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis

1 reference

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22 September 2017

Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

1 reference

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Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins

1 reference

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22 September 2017

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

1 reference

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22 September 2017

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

1 reference

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22 September 2017

NF-kappaB at the crossroads of life and death

1 reference

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22 September 2017

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

1 reference

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22 September 2017

Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

1 reference

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22 September 2017

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

1 reference

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22 September 2017

Signal transduction by the JNK group of MAP kinases

1 reference

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22 September 2017

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

1 reference

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22 September 2017

Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

1 reference

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22 September 2017

Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways

1 reference

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22 September 2017

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase

1 reference

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22 September 2017

Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway

1 reference

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22 September 2017

MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis

1 reference

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22 September 2017

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1 reference

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22 September 2017

Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain

1 reference

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22 September 2017

Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C

1 reference

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22 September 2017

Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453607

22 September 2017

Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation

1 reference

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Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

1 reference

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Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

1 reference

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22 September 2017

MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration

1 reference

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Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism

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25 September 2017

Role of receptor-interacting protein in tumor necrosis factor-alpha -dependent MEKK1 activation

1 reference

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25 September 2017

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

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25 September 2017

Interleukin-1 beta induced activation of NF-kappa B in insulin producing RINm5F cells is prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone

1 reference

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25 September 2017

Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells

1 reference

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Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes

1 reference

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17 June 2018

Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.

1 reference

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17 June 2018

The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death

1 reference

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20 August 2018

beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453607

20 August 2018

Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2453607

1 October 2018

Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silencing gene expression with Dicer-generated siRNA pools

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB07-1670

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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