Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion (Q39945684)

15 September 2017

Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion (English)

1 reference

15 September 2017

Olivia Fromigué

1

1 reference

15 September 2017

Zahia Hamidouche

series ordinal

2

1 reference

15 September 2017

Pierre J Marie

series ordinal

3

1 reference

15 September 2017

language of work or name

English

0 references

publication date

29 August 2008

1 reference

Journal of Biological Chemistry

15 September 2017

1 reference

15 September 2017

283

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15 September 2017

45

1 reference

15 September 2017

30549-30556

1 reference

describes a project that uses

15 September 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2662148/fullTextXML

inferred from PubMed Central ID database lookup

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

22 September 2017

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Matrix metalloproteinases participate in osteosarcoma invasion

22 September 2017

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Essential role of RSK2 in c-Fos-dependent osteosarcoma development

22 September 2017

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Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

22 September 2017

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Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells

22 September 2017

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Harnessing apoptosis for improved anticancer gene therapy

22 September 2017

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AP-1: a double-edged sword in tumorigenesis

22 September 2017

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Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas

22 September 2017

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Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

22 September 2017

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New functions for the matrix metalloproteinases in cancer progression

22 September 2017

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HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

22 September 2017

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Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

22 September 2017

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How matrix metalloproteinases regulate cell behavior

22 September 2017

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22 September 2017

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Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)

22 September 2017

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Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter

22 September 2017

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Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

22 September 2017

1 reference

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

22 September 2017

1 reference

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Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties

22 September 2017

1 reference

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Breast cancer cells release factors that induced apoptosis in human bone marrow stromal cells.

22 September 2017

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Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study

25 September 2017

1 reference

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An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential

25 September 2017

1 reference

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Establishment, characterisation and partial cytokine expression profile of a new human osteosarcoma cell line (CAL 72).

25 September 2017

1 reference

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Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation

17 June 2018

1 reference

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General mechanisms of metastasis

17 June 2018

1 reference

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Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Rho GTPases are over-expressed in human tumors.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Osteosarcoma and other bone cancers.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Immunohistochemical detection of c-fos and c-jun expression in osseous and cartilaginous tumours of the skeleton

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662148

Hematogenous micrometastases in osteosarcoma patients

20 August 2018

1 reference

12 December 2020

Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma

1 reference

12 December 2020

JNK and PI3K differentially regulate MMP-2 and MT1-MMP mRNA and protein in response to actin cytoskeleton reorganization in endothelial cells

1 reference

12 December 2020

Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines

1 reference

12 December 2020

Proteases and protease inhibitors in cancer

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M801436200

1 reference

15 September 2017

1 reference

15 September 2017

PubMed publication ID

18757369

1 reference