Increased constraints on MC4R during primate and human evolution (Q40027560)

16 September 2017

Increased constraints on MC4R during primate and human evolution (English)

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16 September 2017

2

Anke Hinney

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Johannes Hebebrand

6

object named as

Johannes Hebebrand

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Mark Stoneking

7

object named as

Mark Stoneking

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16 September 2017

David A Hughes

1

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16 September 2017

Harald Brumm

3

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16 September 2017

Anne-Kathrin Wermter

4

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16 September 2017

Heike Biebermann

5

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16 September 2017

15 November 2008

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16 September 2017

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16 September 2017

124

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16 September 2017

633-647

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https://scigraph.springernature.com/pub.10.1007/s00439-008-0591-8

16 September 2017

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cites work

A maximum likelihood method for detecting functional divergence at individual codon sites, with application to gene family evolution

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00439-008-0591-8

Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00439-008-0591-8

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene

21 January 2018

1 reference

12 December 2020

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

1 reference

12 December 2020

A human genome diversity cell line panel

1 reference

12 December 2020

Knockout studies defining different roles for melanocortin receptors in energy homeostasis.

1 reference

12 December 2020

Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults

1 reference

12 December 2020

Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutation.

1 reference

12 December 2020

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans

1 reference

12 December 2020

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

12 December 2020

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

1 reference

12 December 2020

Learning from the past: evolution of GPCR functions

1 reference

12 December 2020

A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations

1 reference

12 December 2020

Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization.

1 reference

12 December 2020

A codon-based model of nucleotide substitution for protein-coding DNA sequences

1 reference

12 December 2020

Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene

1 reference

12 December 2020

The genomic rate of adaptive evolution

1 reference

12 December 2020

Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

1 reference

12 December 2020

Genetic structure of human populations

1 reference

12 December 2020

Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index

1 reference

12 December 2020

MUSCLE: a multiple sequence alignment method with reduced time and space complexity

1 reference

12 December 2020

Accuracy and power of statistical methods for detecting adaptive evolution in protein coding sequences and for identifying positively selected sites

1 reference

12 December 2020

Binge eating as a major phenotype of melanocortin 4 receptor gene mutations

1 reference

12 December 2020

Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

1 reference

12 December 2020

Natural selection on protein-coding genes in the human genome

1 reference

12 December 2020

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist

1 reference

12 December 2020

Mutation-selection models of codon substitution and their use to estimate selective strengths on codon usage

1 reference

12 December 2020

Likelihood-based tests of topologies in phylogenetics

1 reference

12 December 2020

G protein-coupled time travel: evolutionary aspects of GPCR research

1 reference

12 December 2020

Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity

1 reference

12 December 2020

PAML 4: phylogenetic analysis by maximum likelihood

1 reference

12 December 2020

Bayes empirical bayes inference of amino acid sites under positive selection

1 reference

12 December 2020

Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

1 reference

12 December 2020

Calibrating a coalescent simulation of human genome sequence variation

1 reference

12 December 2020

Assessing the evolutionary impact of amino acid mutations in the human genome

1 reference

12 December 2020

The human MC4R promoter: characterization and role in obesity

1 reference

12 December 2020

Paleontological evidence to date the tree of life

1 reference

12 December 2020

Insights into recombination from patterns of linkage disequilibrium in humans

1 reference

12 December 2020

DnaSP, DNA polymorphism analyses by the coalescent and other methods

1 reference

12 December 2020

A highly sensitive adenylate cyclase assay

1 reference

12 December 2020

A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity

1 reference

12 December 2020

Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri.

1 reference

12 December 2020

Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany

1 reference

12 December 2020

Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.

1 reference

12 December 2020

Analysis of chimpanzee history based on genome sequence alignments

1 reference

12 December 2020

Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity

1 reference

12 December 2020

Clines, clusters, and the effect of study design on the inference of human population structure

1 reference

12 December 2020

Demographic history and genetic differentiation in apes

1 reference

12 December 2020

MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment

1 reference

12 December 2020

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

1 reference

12 December 2020

DNA mutation detection using denaturing high-performance liquid chromatography (DHPLC).

1 reference

12 December 2020

Synonymous and nonsynonymous rate variation in nuclear genes of mammals.

1 reference

12 December 2020

Identification and functional analysis of novel human melanocortin-4 receptor variants

1 reference

12 December 2020

Positive and negative selection on the human genome

1 reference

12 December 2020

Worldwide human relationships inferred from genome-wide patterns of variation

1 reference

12 December 2020

The delayed rise of present-day mammals

1 reference

12 December 2020

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

1 reference

12 December 2020

Evidence for a Complex Demographic History of Chimpanzees

1 reference

12 December 2020

Generating samples under a Wright-Fisher neutral model of genetic variation

1 reference

12 December 2020

The effect of background selection against deleterious mutations on weakly selected, linked variants

1 reference

12 December 2020

Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study

1 reference

12 December 2020

Evaluation of the maximum likelihood estimate of the evolutionary tree topologies from DNA sequence data, and the branching order in hominoidea

1 reference

12 December 2020

The melanocortin system and energy balance

1 reference

12 December 2020

10.1007/S00439-008-0591-8

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16 September 2017

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