The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice (Q40049468)

16 September 2017

The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice (English)

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16 September 2017

1

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author name string

Linda S Wicker

series ordinal

2

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16 September 2017

9 September 2008

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Journal of Clinical Immunology

16 September 2017

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16 September 2017

28

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16 September 2017

6

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16 September 2017

685-696

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https://scigraph.springernature.com/pub.10.1007/s10875-008-9237-9

16 September 2017

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CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.

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Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

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Multiple immuno-regulatory defects in type-1 diabetes

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Inhibition of human CD4(+)CD25(+high) regulatory T cell function

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The soluble interleukin-2 receptor: biology, function, and clinical application

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Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation

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Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression

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Cutting Edge: Enhanced IL-2 Signaling Can Convert Self-Specific T Cell Response from Tolerance to Autoimmunity

21 January 2018

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Genetic Analysis of Autoimmune Sialadenitis in Nonobese Diabetic Mice: A Major Susceptibility Region on Chromosome 1

21 January 2018

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IL-2R alpha on one cell can present IL-2 to IL-2R beta/gamma(c) on another cell to augment IL-2 signaling.

21 January 2018

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12 December 2020

Interleukin-2 prevention of apoptosis in human neutrophils

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12 December 2020

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

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12 December 2020

A soluble 'anchorminus' interleukin 2 receptor suppresses in vitro interleukin 2-mediated immune responses

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12 December 2020

Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice

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12 December 2020

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

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12 December 2020

The expression of functional IL-2 receptor on activated macrophages depends on the stimulus applied

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12 December 2020

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

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12 December 2020

Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanism

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12 December 2020

CD4+CD25high regulatory cells in human peripheral blood

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12 December 2020

Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta

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12 December 2020

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

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12 December 2020

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

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12 December 2020

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

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12 December 2020

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

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12 December 2020

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

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12 December 2020

Biology of the interleukin-2 receptor

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12 December 2020

Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2

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12 December 2020

A secreted form of the human interleukin 2 receptor encoded by an "anchor minus" cDNA

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12 December 2020

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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12 December 2020

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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12 December 2020

Genetic linkage and association studies of Type I diabetes: challenges and rewards

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12 December 2020

Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells

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12 December 2020

Interleukin-2 augments natural killer cell activity

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12 December 2020

Evidence for two extracellular domains in the human interleukin-2 receptor: localization of IL-2 binding

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12 December 2020

T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells

1 reference

12 December 2020

Three-dimensional structure of a complement control protein module in solution

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12 December 2020

Biophysical characterization of a recombinant soluble interleukin 2 receptor (Tac). Evidence for a monomeric structure

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12 December 2020

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

1 reference

12 December 2020

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

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12 December 2020

The IL-2 receptor complex: its structure, function, and target genes

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12 December 2020

Separable helper factors support B cell proliferation and maturation to Ig secretion

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12 December 2020

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

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12 December 2020

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

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12 December 2020

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

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12 December 2020

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

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12 December 2020

Toward further mapping of the association between the IL2RA locus and type 1 diabetes

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12 December 2020

Interleukin 2 receptor gene expression in normal human T lymphocytes

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12 December 2020

Structure-function relationships for the IL 2-receptor system. IV. Analysis of the sequence and ligand-binding properties of soluble Tac protein

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12 December 2020

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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12 December 2020

A contribution of mouse dendritic cell-derived IL-2 for NK cell activation

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12 December 2020

Signaling from the IL-2 receptor to the nucleus.

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12 December 2020

Oligomerization of IL-2Ralpha

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12 December 2020

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

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12 December 2020

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

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12 December 2020

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

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12 December 2020

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

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12 December 2020

Detection and functional studies of p60-65 (Tac antigen) on activated human B cells

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12 December 2020

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

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12 December 2020

Genomic DNA methylation: the mark and its mediators

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12 December 2020

Alternate signalling pathways from the interleukin-2 receptor

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12 December 2020

A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop.

1 reference

12 December 2020

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

1 reference

12 December 2020

Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3

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12 December 2020

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

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12 December 2020

The monocyte interleukin-2 receptor light chain: production of cell-associated and soluble interleukin-2 receptor by monocytes

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12 December 2020

Diagnosis and treatment of pre-insulin dependent diabetes

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12 December 2020

Susceptibility to type I diabetes: HLA-DQ and DR revisited

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12 December 2020

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

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12 December 2020

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

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12 December 2020

QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2

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12 December 2020

An essential role for Scurfin in CD4+CD25+ T regulatory cells

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12 December 2020

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells

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12 December 2020

Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2

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12 December 2020

Constitutive impaired TCR/CD3-mediated activation of T cells in IDDM patients co-exist with normal co-stimulation pathways

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12 December 2020

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion

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12 December 2020

A T-cell functional phenotype common among autoimmune-prone rodent strains

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12 December 2020

Tracing the action of IL-2 in tolerance to islet-specific antigen

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12 December 2020

The biology of interleukin-2.

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12 December 2020

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

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12 December 2020

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

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12 December 2020

The structure of interleukin-2 complexed with its alpha receptor

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12 December 2020

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

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12 December 2020

Activated CD1d-restricted natural killer T cells secrete IL-2: innate help for CD4+CD25+ regulatory T cells?

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12 December 2020

Expression and function of the IL-2 receptor in activated human plasmacytoid dendritic cells

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12 December 2020

Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity

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12 December 2020

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

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12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

12 December 2020

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects

1 reference

12 December 2020

A function for interleukin 2 in Foxp3-expressing regulatory T cells

1 reference

12 December 2020

Structure function relationships for the IL 2 receptor system. III. Tac protein missing amino acids 102 to 173 (exon 4) is unable to bind IL 2: detection of spliced protein after L cell transfection

1 reference

12 December 2020

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

1 reference

12 December 2020

Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells

1 reference

12 December 2020

SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-susceptibility locus Aod2/Idd3/Eae3

1 reference

12 December 2020

Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power

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12 December 2020

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

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12 December 2020

CD4+CD25high regulatory T cells in human autoimmune diabetes

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12 December 2020

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

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12 December 2020

Biochemical study of a recombinant soluble interleukin-2 receptor. Evidence for a homodimeric structure

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12 December 2020

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

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12 December 2020

Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth

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12 December 2020

Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background

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12 December 2020

Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene

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12 December 2020

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes

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12 December 2020

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

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12 December 2020

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

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12 December 2020

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

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12 December 2020

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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12 December 2020

Expression and role of p75 interleukin 2 receptor on human monocytes

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12 December 2020

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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12 December 2020

Interleukin 2 modulates ion secretion and cell proliferation in cultured human small intestinal enterocytes

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12 December 2020

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

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12 December 2020

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

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12 December 2020

Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells

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12 December 2020

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

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12 December 2020

JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

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12 December 2020

CD4+ CD25+ suppressor T cells: more questions than answers

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12 December 2020

Identification and characterization of two alternative splice variants of human interleukin-2

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12 December 2020

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene

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12 December 2020

Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.

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12 December 2020

Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media

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12 December 2020

Risk alleles for multiple sclerosis identified by a genomewide study

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12 December 2020

Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.

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12 December 2020

Development and function of naturally occurring CD4+CD25+ regulatory T cells

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12 December 2020

Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo

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12 December 2020

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

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12 December 2020

High-resolution genome-wide mapping of histone modifications

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12 December 2020

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

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12 December 2020

A genome-wide search for human type 1 diabetes susceptibility genes

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12 December 2020

Induction of proliferation in vitro of resting human natural killer cells: IL 2 induces into cell cycle most peripheral blood NK cells, but only a minor subset of low density T cells

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12 December 2020

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor

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12 December 2020

Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen

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12 December 2020

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

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12 December 2020

FOXP3 controls regulatory T cell function through cooperation with NFAT

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12 December 2020

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

1 reference

12 December 2020

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

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12 December 2020

The distinct surface of human blood dendritic cells, as observed after an improved isolation method

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12 December 2020

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

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12 December 2020

Fas and the art of lymphocyte maintenance

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12 December 2020

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

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12 December 2020

Effects of interleukin-2 on gene expression in human neutrophils.

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12 December 2020

Genetic control of autoimmune diabetes in the NOD mouse

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12 December 2020

Interleukin-2 and its effects in the central nervous system

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12 December 2020

Anti-CD25 antibodies affect cytokine synthesis pattern of human dendritic cells and decrease their ability to prime allogeneic CD4+ T cells.

1 reference

12 December 2020

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping

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12 December 2020

Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

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12 December 2020

Tolerance, not immunity, crucially depends on IL-2.

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12 December 2020

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

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12 December 2020

Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells

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12 December 2020

Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2

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12 December 2020

Haplotype tagging for the identification of common disease genes

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12 December 2020

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

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12 December 2020

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

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12 December 2020

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

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12 December 2020

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

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12 December 2020

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

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12 December 2020

10.1007/S10875-008-9237-9

Identifiers

DOI

1 reference

PubMed ID

18780166

Dimensions Publication ID

16 September 2017

0 references

1 reference

PubMed ID

18780166