Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis. (Q40052820)

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10 January 2020

title

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis (English)

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10 January 2020

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4

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10 January 2020

Tilman Brummer

2

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10 January 2020

Roger J. Daly

5

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10 January 2020

author name string

Bennett HL

1

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10 January 2020

Jeanes A

3

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10 January 2020

language of work or name

English

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publication date

12 November 2007

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10 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998934%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

27

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10 January 2020

page(s)

2693-2704

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10 January 2020

issue

19

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210928

10 January 2020

exact match

0 references

cites work

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Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps

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Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

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Roles and regulation of stat family transcription factors in human breast cancer

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The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

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Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

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Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase

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Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor

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Role of Gab2 in mammary tumorigenesis and metastasis.

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The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness

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E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts

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Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

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PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

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Regulation of cell-cell junctions by the cytoskeleton.

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

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Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter

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Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function

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Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.

21 January 2018

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21 January 2018

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Critical role for Gab2 in transformation by BCR/ABL

21 January 2018

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Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts

21 January 2018

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Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts.

21 January 2018

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TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.

21 January 2018

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21 January 2018

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21 January 2018

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Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

21 January 2018

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Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules

21 January 2018

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Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

21 January 2018

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Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration

21 January 2018

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Epidermal Growth Factor-induced DNA Synthesis

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210928

inferred from DOI database lookup

7 January 2021

based on heuristic

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210928

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210928

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998934%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 January 2020

0 references

1 reference