Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity (Q40054881)

16 September 2017

title

Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity (English)

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16 September 2017

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Lu Y

1

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16 September 2017

Peng ZG

2

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16 September 2017

Yuan TT

3

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16 September 2017

Yin QQ

4

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16 September 2017

Xia L

5

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16 September 2017

Chen GQ

6

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16 September 2017

publication date

8 November 2007

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16 September 2017

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16 September 2017

volume

22

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16 September 2017

issue

2

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16 September 2017

page(s)

378-386

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Fusion genes in leukemia: an emerging network

16 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405020

The 8;21 translocation in leukemogenesis

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AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

21 January 2018

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KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

21 January 2018

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Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

21 January 2018

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Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

21 January 2018

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Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.

21 January 2018

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Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal

21 January 2018

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Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

21 January 2018

1 reference

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Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells

21 January 2018

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The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

21 January 2018

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Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms.

21 January 2018

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Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis

21 January 2018

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Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

21 January 2018

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Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner.

21 January 2018

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Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoprotein

21 January 2018

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Apoptosis-based therapies for hematologic malignancies

21 January 2018

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Williams-Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO.

21 January 2018

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

21 January 2018

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MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

21 January 2018

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Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation

21 January 2018

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Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view

21 January 2018

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Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.

21 January 2018

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Many cuts to ruin: a comprehensive update of caspase substrates

21 January 2018

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Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis

21 January 2018

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Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

21 January 2018

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AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

21 January 2018

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Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

21 January 2018

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Caspase Activity and a Specific Cytochrome C Are Required for Sperm Differentiation in Drosophila

21 January 2018

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A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

21 January 2018

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Non-apoptotic functions of caspases in cellular proliferation and differentiation

21 January 2018

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Erythropoietin activates caspase-3 and downregulates CAD during erythroid differentiation in TF-1 cells - a protection mechanism against DNA fragmentation

21 January 2018

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Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2405020

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405020

JAK2 seems to be a typical cooperating mutation in therapy-related t(8;21)/ AML1-ETO-positive AML

21 January 2018

1 reference

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7 January 2021

c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405020

7 January 2021

Neural stem cell differentiation is dependent upon endogenous caspase 3 activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405020

7 January 2021

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405020

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2405020

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Dimensions Publication ID

16 September 2017

1031053726

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1 reference