Current strategies for the treatment of Alzheimer's disease and other tauopathies (Q36596669)

15 August 2017

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title

Current strategies for the treatment of Alzheimer's disease and other tauopathies (English)

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15 August 2017

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2

Leonard Petrucelli

1 reference

15 August 2017

Chad A Dickey

1

1 reference

PubMed ID

16981824

15 August 2017

language of work or name

English

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publication date

1 October 2006

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Expert Opinion on Therapeutic Targets

15 August 2017

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15 August 2017

10

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15 August 2017

5

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15 August 2017

665-676

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

15 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Presenilins in memory, Alzheimer's disease, and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Neurodegenerative disorders with extensive tau pathology: a comparative study and review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Association of an extended haplotype in the tau gene with progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Tau haplotypes regulate transcription and are associated with Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Linkage disequilibrium and association of MAPT H1 in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Acetylcholinesterase and its inhibition in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Acetylcholinesterase inhibitors: novel activities of old molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Memantine in moderate-to-severe Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Rivastigmine in the treatment of parkinsonian psychosis and cognitive impairment: preliminary findings from an open trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Neurotrophins are required for nerve growth during development.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Altered microtubule organization in small-calibre axons of mice lacking tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

The development of potent and selective bisarylmaleimide GSK3 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Cytoskeletal integrity as a drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Pathways of chaperone-mediated protein folding in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

21 January 2018

Heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Hsp90: a specialized but essential protein-folding tool

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Chaperones increase association of tau protein with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

CHIP activates HSF1 and confers protection against apoptosis and cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Peripheral hyperinsulinemia promotes tau phosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Timing requirements for insulin/IGF-1 signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Long-lived Drosophila with overexpressed dFOXO in adult fat body

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

GROalpha/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation-a role in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

Tau is essential to beta -amyloid-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.665

10.1517/14728222.10.5.665

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16981824