Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. (Q40068149)

17 September 2017

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. (English)

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17 September 2017

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dengue virus protein NS1

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modulation by virus of host process

inferred from abstract

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author

Antje Blumenthal

3

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17 September 2017

Naphak Modhiran

1

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Katryn J. Stacey

object named as

Katryn J Stacey

6

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Alan G Baxter

object named as

Alan G Baxter

4

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Daniel Watterson

object named as

Daniel Watterson

2

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author name string

Paul R Young

5

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17 September 2017

21 February 2017

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Immunology & Cell Biology

17 September 2017

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17 September 2017

95

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17 September 2017

491-495

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17 September 2017

5

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https://scigraph.springernature.com/pub.10.1038/icb.2017.5

17 September 2017

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cites work

The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker

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Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

21 January 2018

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Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination

21 January 2018

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

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Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1.

21 January 2018

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Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.

21 January 2018

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HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-κB Pathway.

21 January 2018

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Activation of TLR2 and TLR6 by Dengue NS1 Protein and Its Implications in the Immunopathogenesis of Dengue Virus Infection

21 January 2018

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Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

21 January 2018

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Novel bacterial lipoprotein structures conserved in low-GC content gram-positive bacteria are recognized by Toll-like receptor 2.

21 January 2018

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Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System

21 January 2018

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Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

21 January 2018

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Structure of the dengue virus glycoprotein non-structural protein 1 by electron microscopy and single-particle analysis

21 January 2018

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N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

21 January 2018

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Determination of the disulfide bond arrangement of dengue virus NS1 protein

21 January 2018

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Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

21 January 2018

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Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms

21 January 2018

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Postulates for validating TLR4 agonists

21 January 2018

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Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock

21 January 2018

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Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections

21 January 2018

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High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever

21 January 2018

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Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E

21 January 2018

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Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis.

21 January 2018

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Lipopolysaccharide levels are elevated in dengue virus infected patients and correlate with disease severity

21 January 2018

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Electroporation and DNA-dependent cell death in murine macrophages

21 January 2018

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Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2017.5

7 January 2021

Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2

1 reference

https://api.crossref.org/works/10.1038%2FICB.2017.5

7 January 2021

An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients

1 reference

https://api.crossref.org/works/10.1038%2FICB.2017.5

7 January 2021

Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leucocytes from human blood by the Hypaque-Ficoll method

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https://api.crossref.org/works/10.1038%2FICB.2017.5

7 January 2021

Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28220810

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/ICB.2017.5

1 reference

PubMed ID

28220810

Dimensions Publication ID

17 September 2017

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1 reference

PubMed ID

28220810