Postulates for validating TLR4 agonists (Q27023992)

language of work or name

1 reference

February 2015

1 reference

European Journal of Immunology

published in

1 reference

volume

45

1 reference

page(s)

356-70

1 reference

issue

2

1 reference

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

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Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14.

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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A family of human receptors structurally related to Drosophila Toll

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

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Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.

21 January 2018

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

21 January 2018

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

21 January 2018

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Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

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The Toll-like receptor 4 region Glu24-Pro34 is critical for interaction with MD-2.

21 January 2018

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

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Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin

21 January 2018

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

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CD14 is required for MyD88-independent LPS signaling.

21 January 2018

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Signal integration in lipopolysaccharide (LPS)-stimulated murine macrophages

21 January 2018

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Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

21 January 2018

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Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells

21 January 2018

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Human Toll-like receptor 4 recognizes host-specific LPS modifications.

21 January 2018

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Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica

21 January 2018

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Variability in the lipooligosaccharide structure and endotoxicity among Bordetella pertussis strains.

21 January 2018

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The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition

21 January 2018

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Structure and function of Toll receptors and their ligands

21 January 2018

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TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.201444462

A mouse model of Salmonella typhi infection

21 January 2018

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21 January 2018

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Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.201444462

Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.201444462

Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.201444462

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

21 January 2018

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Transcriptional network dynamics in macrophage activation

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.201444462

LPS/TLR4 signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Thematic review series: The immune system and atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Tolerance, danger, and the extended family

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.201444462

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

The extra domain A of fibronectin activates Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Gangliosides trigger inflammatory responses via TLR4 in brain glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Characterization of heme as activator of Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

High mobility group box 1 protein interacts with multiple Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Differential activation of murine macrophages by angelan and LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Helicobacter pylori protein HP0175 transactivates epidermal growth factor receptor through TLR4 in gastric epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

A polymeric bacterial protein activates dendritic cells via TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Cutting edge: Gln22 of mouse MD-2 is essential for species-specific lipopolysaccharide mimetic action of taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Solution structure of polymyxins B and E and effect of binding to lipopolysaccharide: an NMR and molecular modeling study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Heat-shock protein 70 and heat-shock protein 90 associate with Toll-like receptor 4 in response to bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

C-reactive protein-induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Taxanes inhibit human TLR4 signaling by binding to MD-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Toll-like receptor 4 signalling is neither sufficient nor required for oxidised phospholipid mediated induction of interleukin-8 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Paclitaxel binding to human and murine MD-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

MD-2 as the target of curcumin in the inhibition of response to LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Cryopyrin activates the inflammasome in response to toxins and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Essential role of MD-2 in LPS responsiveness and TLR4 distribution.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Nonspecific interactions alter lipopolysaccharide patterns and protein mobility on sodium dodecyl sulfate polyacrylamide gels

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Bacterial endotoxin is an active component of cigarette smoke

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Endotoxin-free heat-shock protein 70 fails to induce APC activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Neutralization of endotoxin in vitro and in vivo by a human lactoferrin-derived peptide

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Saturated fatty acids do not directly stimulate Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444462

7 January 2021

Identifiers

DOI

10.1002/EJI.201444462

1 reference

Consolidated OpenCitations Corpus – April 2017

2237014

2237014

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference