MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N'-nitro-N'-nitrosoguanidine (Q40084513)

17 September 2017

MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N'-nitro-N'-nitrosoguanidine (English)

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17 September 2017

Wan-Ju Kim

1

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17 September 2017

Baskaran Rajasekaran

series ordinal

2

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17 September 2017

Kevin D Brown

series ordinal

3

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17 September 2017

language of work or name

English

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publication date

5 September 2007

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Journal of Biological Chemistry

17 September 2017

11

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based on heuristic

inferred from page(s)

published in

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17 September 2017

282

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17 September 2017

44

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17 September 2017

32021-32031

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Checkpoints: controls that ensure the order of cell cycle events

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Cell Cycle Checkpoints, Genomic Integrity, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Multiple mutations and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Mismatch repair and DNA damage signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

O6-methylguanine-DNA methyltransferase-defective human cell mutant: O6-methylguanine, DNA strand breaks and cytotoxicity.

21 January 2018

1 reference

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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Sounding the alarm: protein kinase cascades activated by stress and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

MAPK pathways in radiation responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

1 reference

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AP-1 function and regulation

21 January 2018

1 reference

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Integrating stress-response and cell-cycle checkpoint pathways

21 January 2018

1 reference

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

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The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

21 January 2018

1 reference

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c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Three distinct signalling responses by murine fibroblasts to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Interaction between ATM protein and c-Abl in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Recombinant ATM protein complements the cellular A-T phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Ataxia telangiectasia mutated is essential during adult neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

N-methyl-N'-nitro-N-nitrosoguanidine activates cell-cycle arrest through distinct mechanisms activated in a dose-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

ATM and ATR: networking cellular responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

The mismatch repair system is required for S-phase checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Dimerization of MLH1 and PMS2 Limits Nuclear Localization of MutLα

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Apoptosis induced by topoisomerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage

21 January 2018

1 reference

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Induction of base damages representing a high risk site for double-strand DNA break formation in genomic DNA by exposure of cells to DNA damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

21 January 2018

1 reference

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AP-1 as a regulator of cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701451200

21 January 2018

Identifiers

DOI

10.1074/JBC.M701451200

1 reference

17 September 2017

1 reference