What makes tropomyosin an actin binding protein? A perspective (Q40092483)

17 September 2017

What makes tropomyosin an actin binding protein? A perspective (English)

1 reference

17 September 2017

Sarah E Hitchcock-DeGregori

series ordinal

1

1 reference

PMC publication ID

2856766

17 September 2017

Abhishek Singh

series ordinal

2

1 reference

17 September 2017

29 December 2009

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Journal of Structural Biology

17 September 2017

1 reference

17 September 2017

170

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17 September 2017

2

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17 September 2017

319-324

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A peek into tropomyosin binding and unfolding on the actin filament

17 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin and the steric mechanism of muscle regulation.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin: function follows structure

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Structure of the N Terminus of a Nonmuscle α-Tropomyosin in Complex with the C Terminus: Implications for Actin Binding † ‡

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Gestalt-binding of tropomyosin to actin filaments.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Fifty years of coiled-coils and alpha-helical bundles: a close relationship between sequence and structure

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Two-crystal structures of tropomyosin C-terminal fragment 176-273: exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin-based regulation of the actin cytoskeleton in time and space

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Conformational entropy in molecular recognition by proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Breaking symmetry in protein dimers: designs and functions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Structure of the mid-region of tropomyosin: bending and binding sites for actin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Structure and interactions of the carboxyl terminus of striated muscle alpha-tropomyosin: it is important to be flexible

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Deciphering the design of the tropomyosin molecule

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Importance of internal regions and the overall length of tropomyosin for actin binding and regulatory function

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Speeding molecular recognition by using the folding funnel: the fly-casting mechanism

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Crystal structure of tropomyosin at 7 Angstroms resolution

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin positions in regulated thin filaments revealed by cryoelectron microscopy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Integral repeats and a continuous coiled coil are required for binding of striated muscle tropomyosin to the regulated actin filament

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Construction of an atomic model for tropomyosin and implications for interactions with actin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin has discrete actin-binding sites with sevenfold and fourteenfold periodicities

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Heptad breaks in alpha-helical coiled coils: stutters and stammers

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin period 3 is essential for enhancement of isometric tension in thin filament-reconstituted bovine myocardium

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Identification of a unique "stability control region" that controls protein stability of tropomyosin: A two-stranded alpha-helical coiled-coil

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Functions of tropomyosin's periodic repeats

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Dynamics of the muscle thin filament regulatory switch: the size of the cooperative unit.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

The 14-fold periodicity in alpha-tropomyosin and the interaction with actin.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

The amino acid sequence of rabbit skeletal alpha-tropomyosin. The NH2-terminal half and complete sequence

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Close encounters of the third kind: disordered domains and the interactions of proteins.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Conserved Asp-137 imparts flexibility to tropomyosin and affects function

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

The second half of the fourth period of tropomyosin is a key region for Ca(2+)-dependent regulation of striated muscle thin filaments.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Stabilizing and destabilizing clusters in the hydrophobic core of long two-stranded alpha-helical coiled-coils

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

In vitro functional characterization of bacterially expressed human fibroblast tropomyosin isoforms and their chimeric mutants.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

An atomic model of the unregulated thin filament obtained by X-ray fiber diffraction on oriented actin-tropomyosin gels.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Interaction of tropomyosin-troponin with actin filaments.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856766

Tropomyosin's periods are quasi-equivalent for actin binding but have specific regulatory functions

20 August 2018

1 reference

12 December 2020

Dual requirement for flexibility and specificity for binding of the coiled-coil tropomyosin to its target, actin

1 reference

12 December 2020

Fluorescence studies of the conformation of pyrene-labeled tropomyosin: effects of F-actin and myosin subfragment 1

1 reference

12 December 2020

Complexes of smooth muscle tropomyosin with F-actin studied by differential scanning calorimetry

1 reference

12 December 2020

Sequence repeats in α-tropomyosin

1 reference

12 December 2020

Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation

1 reference

12 December 2020

Analysis of the primary sequence of α-tropomyosin from rabbit skeletal muscle

1 reference

12 December 2020

Effects of tropomyosin internal deletions on thin filament function

1 reference

12 December 2020

Crystal structures of tropomyosin: flexible coiled-coil

1 reference

12 December 2020

The active state of the thin filament is destabilized by an internal deletion in tropomyosin

1 reference

12 December 2020

Excimer fluorescence of pyrenyliodoacetamide-labeled tropomyosin: a probe of the state of tropomyosin in reconstituted muscle thin filaments

1 reference

12 December 2020

Co-operative blocks in tropomyosin

1 reference

12 December 2020

10.1016/J.JSB.2009.12.013

Identifiers

DOI

1 reference

17 September 2017

1 reference

PMC publication ID

2856766

17 September 2017

PubMed publication ID

20036744

1 reference

PMC publication ID

2856766