Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer (Q40113117)

17 September 2017

title

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer (English)

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17 September 2017

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18

Gabriela Chiosis

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Cristina C Clement

object named as

Cristina C Clement

8

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Joan Massagué Solé

object named as

Joan Massague

14

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Peter Wipf

13

object named as

Peter Wipf

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Anna Rodina

1

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Maria Vilenchik

2

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Kamalika Moulick

3

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Julia Aguirre

4

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Joungnam Kim

5

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Anne Chiang

6

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Julie Litz

7

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Yanlong Kang

9

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Yuhong She

10

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Nian Wu

11

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Sara Felts

12

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Xuejun Jiang

15

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Jeffrey L Brodsky

16

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Geoffrey W Krystal

17

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Gabriela Chiosis

18

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publication date

1 July 2007

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17 September 2017

published in

Nature Chemical Biology

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17 September 2017

volume

3

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issue

8

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17 September 2017

page(s)

498-507

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HSP90 as a new therapeutic target for cancer therapy: the story unfolds

17 September 2017

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

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Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis

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UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance

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Escaping cell death: survival proteins in cancer

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Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

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Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

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7 January 2021

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

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The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy

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7 January 2021

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

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7 January 2021

Negative regulation of the Apaf-1 apoptosome by Hsp70

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7 January 2021

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives

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7 January 2021

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

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7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2007.10

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17 September 2017

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