Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1. (Q40117579)

17 September 2017

title

Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1. (English)

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17 September 2017

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Likui Yang

1

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17 September 2017

Jong-Sup Bae

series ordinal

2

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17 September 2017

Chandrashekhara Manithody

series ordinal

3

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17 September 2017

Alireza R Rezaie

series ordinal

4

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17 September 2017

language of work or name

English

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publication date

19 June 2007

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Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

35

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17 September 2017

page(s)

25493-25500

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Structure and function of protein C.

17 September 2017

cites work

1 reference

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The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

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Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

21 January 2018

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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

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PAR1 cleavage and signaling in response to activated protein C and thrombin.

21 January 2018

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Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells

21 January 2018

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Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

21 January 2018

1 reference

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Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va.

21 January 2018

1 reference

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Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

21 January 2018

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Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C.

21 January 2018

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Exosite-dependent regulation of factor VIIIa by activated protein C.

21 January 2018

1 reference

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Exosite-dependent regulation of the protein C anticoagulant pathway

21 January 2018

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Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

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The crystal structure of the endothelial protein C receptor and a bound phospholipid

21 January 2018

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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

21 January 2018

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Structure of human des(1-45) factor Xa at 2.2 A resolution

21 January 2018

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Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa

21 January 2018

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Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C

21 January 2018

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Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties

21 January 2018

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Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

21 January 2018

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A fluorometric assay for the quantitation of cell adherence to endothelial cells

21 January 2018

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Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells

21 January 2018

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Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

21 January 2018

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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

21 January 2018

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Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

21 January 2018

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M702131200

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17 September 2017

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