Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. (Q40136363)

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30 December 2019

title

Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation (English)

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30 December 2019

7

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30 December 2019

Johannes V. Swinnen

9

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30 December 2019

4

Paul P Van Veldhoven

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30 December 2019

author name string

Koen Brusselmans

1

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30 December 2019

Leen Timmermans

2

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30 December 2019

Tine Van de Sande

3

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30 December 2019

Guimin Guan

5

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30 December 2019

Ishaiahu Shechter

6

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30 December 2019

Guido Verhoeven

8

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language of work or name

English

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publication date

5 May 2007

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Journal of Biological Chemistry

30 December 2019

published in

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30 December 2019

volume

282

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30 December 2019

issue

26

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30 December 2019

page(s)

18777-18785

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Functional rafts in cell membranes

30 December 2019

cites work

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Lipid rafts: contentious only from simplistic standpoints

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Lipid rafts and signal transduction

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Cholesterol and prostate cancer

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The role of cholesterol in prostate cancer

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Statins: the new aspirin?

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Statins and cancer prevention

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p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases

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Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis.

21 January 2018

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Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling

21 January 2018

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Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

21 January 2018

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Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents

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Regulation of the mevalonate pathway

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Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway

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Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy

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The Mevalonate Synthesis Pathway as a Therapeutic Target in Cancer

21 January 2018

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Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

21 January 2018

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Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells.

21 January 2018

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

21 January 2018

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Androgen activation of the sterol regulatory element-binding protein pathway: Current insights.

21 January 2018

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Androgens, lipogenesis and prostate cancer.

21 January 2018

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Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins

21 January 2018

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Structure and regulation of mammalian squalene synthase

21 January 2018

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Molecular cloning and functional analysis of the promoter of the human squalene synthase gene

21 January 2018

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Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene

21 January 2018

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Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation

21 January 2018

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Androgen receptor modifications in prostate cancer cells upon long-termandrogen ablation and antiandrogen treatment.

21 January 2018

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RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells

21 January 2018

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Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP.

21 January 2018

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Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

21 January 2018

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Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

21 January 2018

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Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes

21 January 2018

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Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M611763200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17483544%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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