The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation (Q40167543)

18 September 2017

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation (English)

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18 September 2017

7

Saelens X

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18 September 2017

Kalai M

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18 September 2017

Suin V

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18 September 2017

Festjens N

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18 September 2017

Meeus A

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18 September 2017

Bernis A

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18 September 2017

Wang XM

6

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18 September 2017

Vandenabeele P

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18 September 2017

23 February 2007

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Cell Death & Differentiation

18 September 2017

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18 September 2017

14

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18 September 2017

5

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18 September 2017

1050-1059

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402110

18 September 2017

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PKR; a sentinel kinase for cellular stress

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A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

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Eukaryotic initiation factor eIF2.

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Virus clearance through apoptosis-dependent phagocytosis of influenza A virus-infected cells by macrophages

21 January 2018

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

21 January 2018

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Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells

21 January 2018

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Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

21 January 2018

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Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

21 January 2018

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Protein synthesis persists during necrotic cell death

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

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Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

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Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

21 January 2018

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Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

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Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis.

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A novel caspase-2 complex containing TRAF2 and RIP1.

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Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

21 January 2018

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Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance.

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Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

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Inhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA

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The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

21 January 2018

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TRAF family proteins link PKR with NF-kappa B activation

21 January 2018

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Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

21 January 2018

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Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

21 January 2018

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Caspase-independent cell killing by Fas-associated protein with death domain

21 January 2018

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Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

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Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

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Dynamic Flexibility of Double-stranded RNA Activated PKR in Solution

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TIR domain-containing adaptors regulate TLR signaling pathways

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7 January 2021

A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.

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7 January 2021

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

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7 January 2021

Necrosis is associated with IL-6 production but apoptosis is not.

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7 January 2021

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

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7 January 2021

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402110

7 January 2021

Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIP

1 reference

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7 January 2021

Optimization of experimental variables influencing reporter gene expression in hepatoma cells following calcium phosphate transfection

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402110

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Dimensions Publication ID

18 September 2017

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