PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response (Q40198127)

18 September 2017

title

PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response (English)

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18 September 2017

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Ayllón V

1

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18 September 2017

O'connor R

series ordinal

2

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18 September 2017

language of work or name

English

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publication date

11 December 2006

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18 September 2017

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18 September 2017

volume

26

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18 September 2017

issue

24

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18 September 2017

page(s)

3451-3461

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Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells

18 September 2017

cites work

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Cancer in xeroderma pigmentosum and related disorders of DNA repair

21 January 2018

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Regulation of growth-related genes by interleukin-6 in murine myeloma cells

21 January 2018

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Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis

21 January 2018

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PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase

21 January 2018

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Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression

21 January 2018

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H2AX: the histone guardian of the genome

21 January 2018

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Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839).

21 January 2018

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Expression and phosphorylation of TOPK during spermatogenesis

21 January 2018

1 reference

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Characterization of PDZ-binding kinase, a mitotic kinase

21 January 2018

1 reference

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Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair

21 January 2018

1 reference

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Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage

21 January 2018

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Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer

21 January 2018

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MAP kinases and cell migration

21 January 2018

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RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

Nucleotide excision repair is not required for the antiapoptotic function of insulin-like growth factor 1.

21 January 2018

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DNA damage checkpoint and repair centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth

21 January 2018

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Gene expression profiles in cells transformed by overexpression of the IGF-I receptor

21 January 2018

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Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

21 January 2018

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DNA repair inhibition: a selective tumour targeting strategy.

21 January 2018

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IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB.

21 January 2018

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H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks

21 January 2018

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Characterization of a MAPKK-like protein kinase TOPK

21 January 2018

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IGF-I receptor, cell-cell adhesion, tumour development and progression

21 January 2018

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The p38-mediated stress-activated checkpoint. A rapid response system for delaying progression through antephase and entry into mitosis

21 January 2018

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Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1.

21 January 2018

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Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells

21 January 2018

1 reference

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Expression of PDZ-binding kinase (PBK) is regulated by cell cycle-specific transcription factors E2F and CREB/ATF.

21 January 2018

1 reference

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Regulation of IGF-I receptor signaling in tumor cells.

21 January 2018

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer

21 January 2018

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Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors

21 January 2018

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Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

21 January 2018

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Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

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Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor

21 January 2018

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Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.

21 January 2018

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Control of cell survival by IGF signaling pathways.

21 January 2018

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A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses.

21 January 2018

1 reference

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Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210142

21 January 2018

Identifiers

DOI

10.1038/SJ.ONC.1210142

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Dimensions Publication ID

18 September 2017

1012347251

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