6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation (Q40200614)

18 September 2017

title

6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation (English)

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18 September 2017

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Yoo YG

1

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18 September 2017

Na TY

2

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18 September 2017

Yang WK

3

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18 September 2017

Kim HJ

4

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18 September 2017

Lee IK

5

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18 September 2017

Kong G

6

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18 September 2017

Chung JH

7

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18 September 2017

Lee MO

8

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18 September 2017

language of work or name

English

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publication date

4 December 2006

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18 September 2017

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18 September 2017

volume

26

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18 September 2017

issue

26

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18 September 2017

page(s)

3823-3834

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210149

18 September 2017

exact match

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cites work

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF

21 January 2018

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Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

21 January 2018

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Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

21 January 2018

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Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

21 January 2018

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

21 January 2018

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Analysis of ARD1 function in hypoxia response using retroviral RNA interference

21 January 2018

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Human vascular endothelial cells in culture. Growth and DNA synthesis

21 January 2018

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Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNF alpha -induced PAI-1 expression

21 January 2018

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A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily

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Nur77 family of nuclear hormone receptors

21 January 2018

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

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Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

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Characterization of ARD1 variants in mammalian cells

21 January 2018

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Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells

21 January 2018

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Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression

21 January 2018

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

21 January 2018

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Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.

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Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway

21 January 2018

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

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The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells.

21 January 2018

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Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferation

21 January 2018

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Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis

21 January 2018

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Prolonged survival of human-kidney homografts by immunosuppressive drug therapy

21 January 2018

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Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1

21 January 2018

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

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NOR-1 is involved in VEGF-induced endothelial cell growth.

21 January 2018

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

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Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

21 January 2018

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Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.

21 January 2018

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses

21 January 2018

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Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas

21 January 2018

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Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.

21 January 2018

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Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity

21 January 2018

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Dopamine neuron agenesis in Nurr1-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells

21 January 2018

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Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

Thiopurine biology and pharmacology

21 January 2018

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7 January 2021

Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice

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Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha

1 reference

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Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210149

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Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation

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Azathioprine and 6-mercaptopurine alter the nucleotide balance in endothelial cells

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210149

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Dimensions Publication ID

18 September 2017

1010277752

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1 reference