Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. (Q40207958)

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21 December 2019

title

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines (English)

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21 December 2019

3

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21 December 2019

author name string

Chihiro Sato

series ordinal

1

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21 December 2019

Yuichi Morohashi

series ordinal

2

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21 December 2019

Takeshi Iwatsubo

series ordinal

4

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21 December 2019

language of work or name

English

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publication date

1 November 2006

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21 December 2019

published in

Journal of Neuroscience

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21 December 2019

volume

26

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21 December 2019

issue

46

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21 December 2019

page(s)

12081-12088

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Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins

21 December 2019

cites work

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12 December 2020

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin

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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

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A model for the topology of excitatory amino acid transporters determined by the extracellular accessibility of substituted cysteines

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

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12 December 2020

The kamikaze approach to membrane transport

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12 December 2020

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

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12 December 2020

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

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12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

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12 December 2020

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

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12 December 2020

Designed Helical Peptides Inhibit an Intramembrane Protease

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12 December 2020

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

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12 December 2020

X-ray structure of a protein-conducting channel

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12 December 2020

Proteolysis within the membrane: rhomboids revealed

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12 December 2020

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

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12 December 2020

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

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12 December 2020

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

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12 December 2020

A nine-transmembrane domain topology for presenilin 1

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12 December 2020

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

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12 December 2020

gamma-secretase as a therapeutic target for treatment of Alzheimer's disease

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12 December 2020

Three-dimensional structure of the γ-secretase complex

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12 December 2020

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

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12 December 2020

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

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12 December 2020

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

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12 December 2020

The gamma-secretase complex: membrane-embedded proteolytic ensemble

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12 December 2020

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

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12 December 2020

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

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12 December 2020

Inside-Out Red Cell Membrane Vesicles: Preparation and Purification

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12 December 2020

Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator.

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12 December 2020

Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines.

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12 December 2020

Membrane topology of the C. elegans SEL-12 presenilin

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12 December 2020

Protein topology of presenilin 1

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12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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12 December 2020

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

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12 December 2020

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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12 December 2020

The location of the gate in the acetylcholine receptor channel

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12 December 2020

Substituted-cysteine accessibility method

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12 December 2020

Transmembrane topology mapping using biotin-containing sulfhydryl reagents

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12 December 2020

A reentrant loop domain in the glutamate carrier EAAT1 participates in substrate binding and translocation

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12 December 2020

10.1523/JNEUROSCI.3614-06.2006

Identifiers

DOI

1 reference

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21 December 2019

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21 December 2019

PubMed publication ID

17108181

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