Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1 (Q28277779)

1

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Taisuke Tomita

2

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Chihiro Sato

3

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Toshio Kitamura

4

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Yuichi Morohashi

5

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Takeshi Iwatsubo

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

23 December 2005

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published in

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volume

280

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issue

51

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page(s)

41967-75

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cites work

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Membrane topology of gamma-secretase component PEN-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

PEN-2 enhances gamma-cleavage after presenilin heterodimer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Site-directed, Ligase-Independent Mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A novel method for viral display of ER membrane proteins on budded baculovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Evidence for a six-transmembrane domain structure of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Presenilin mutations line up along transmembrane alpha-helices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Gamma-secretase complex assembly within the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Association of active gamma-secretase complex with lipid rafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509066200

21 January 2018

Identifiers

DOI

10.1074/JBC.M509066200

1 reference

Consolidated OpenCitations Corpus – April 2017

4266276

4266276

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference