Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation (Q40210920)

18 September 2017

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation (English)

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18 September 2017

Peter C W Lee

1

1 reference

PubMed ID

17090658

18 September 2017

Andrew D Nguyen

series ordinal

2

1 reference

PubMed ID

17090658

18 September 2017

Russell A Debose-Boyd

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3

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18 September 2017

7 November 2006

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Journal of Lipid Research

18 September 2017

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18 September 2017

48

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18 September 2017

2

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18 September 2017

318-327

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Regulation of the mevalonate pathway

18 September 2017

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Protein sensors for membrane sterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Transport-Dependent Proteolysis of SREBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

The sterol-sensing domain: multiple families, a unique role?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600476-JLR200

10.1194/JLR.M600476-JLR200

21 January 2018

Identifiers

DOI

1 reference

18 September 2017

1 reference

PubMed ID

17090658