Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). (Q40220627)

18 September 2017

Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). (English)

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18 September 2017

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author name string

W Michael Caudle

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18 September 2017

Thomas S Guillot

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18 September 2017

Jodi L Watson

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18 September 2017

Eiko Nakamaru-Ogiso

5

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18 September 2017

Byoung Boo Seo

6

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18 September 2017

Todd B Sherer

7

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18 September 2017

J Timothy Greenamyre

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18 September 2017

Takao Yagi

9

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18 September 2017

Akemi Matsuno-Yagi

10

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18 September 2017

Gary W Miller

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18 September 2017

12 October 2006

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18 September 2017

Toxicological Sciences

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18 September 2017

95

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18 September 2017

1

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18 September 2017

196-204

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Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene

18 September 2017

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Parkinson's disease: mechanisms and models

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Liposomal and viral vectors for gene therapy of the central nervous system.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Complex I and Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Coenzyme Q(10) provides neuroprotection in iron-induced apoptosis in dopaminergic neurons

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Dopamine efflux by MPTP and hydroxyl radical generation

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Nitric oxide and MPP+-induced hydroxyl radical generation

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Characterization of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Etiology and pathogenesis of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Glucose transporter Glut 5 expression in microglial cells.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Paraquat neurotoxicity is distinct from that of MPTP and rotenone.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

21 January 2018

Mitochondrial disease

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Grid performance test to measure behavioral impairment in the MPTP-treated-mouse model of parkinsonism

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Bioactivation of MPTP: reactive metabolites and possible biochemical sequelae

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

Genetic clues to the pathogenesis of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL133

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFL133

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18 September 2017

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