Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology (Q40227379)

18 September 2017

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology (English)

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18 September 2017

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Stéphane Duvezin-Caubet

object named as

Stéphane Duvezin-Caubet

1

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Johannes Wagener

object named as

Johannes Wagener

3

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Nils-Göran Larsson

10

object named as

Nils-Göran Larsson

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18 September 2017

Ravi Jagasia

2

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18 September 2017

Sabine Hofmann

4

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18 September 2017

Aleksandra Trifunovic

5

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18 September 2017

Anna Hansson

6

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18 September 2017

Anne Chomyn

7

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18 September 2017

Matthias F Bauer

8

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18 September 2017

Giuseppe Attardi

9

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18 September 2017

Walter Neupert

11

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18 September 2017

Andreas S Reichert

12

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18 September 2017

language of work or name

English

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publication date

26 September 2006

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Journal of Biological Chemistry

18 September 2017

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18 September 2017

281

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18 September 2017

37972-37979

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18 September 2017

49

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

18 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Nuclear genetic defects of oxidative phosphorylation

21 January 2018

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Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Mitochondria and degenerative disorders

21 January 2018

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Mitochondrial respiratory-chain diseases

21 January 2018

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Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

21 January 2018

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Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

21 January 2018

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Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease

21 January 2018

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

21 January 2018

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The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation.

21 January 2018

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Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

21 January 2018

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The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

21 January 2018

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Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA.

21 January 2018

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Separate fusion of outer and inner mitochondrial membranes.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Mitochondrial fusion intermediates revealed in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

OPA1 requires mitofusin 1 to promote mitochondrial fusion

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

A mitochondrial encephalomyopathy: the first case with an established defect at the level of coenzyme Q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Genetic and structural characterization of the human mitochondrial inner membrane translocase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

21 January 2018

How mitochondria fuse

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https://api.crossref.org/works/10.1074%2FJBC.M606059200

Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast

21 January 2018

1 reference

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Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606059200

21 January 2018

Identifiers

DOI

10.1074/JBC.M606059200

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18 September 2017

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