Secretion of the Notch-1 Abeta-like peptide during Notch signaling (Q40325565)

19 September 2017

Secretion of the Notch-1 Abeta-like peptide during Notch signaling (English)

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19 September 2017

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7

Christian Haass

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author name string

Akio Fukumori

2

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19 September 2017

Jingwei Jiang

3

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19 September 2017

Naohiro Itoh

4

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19 September 2017

Ryo Kimura

5

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19 September 2017

Harald Steiner

6

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19 September 2017

Shinji Tagami

8

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19 September 2017

Masatoshi Takeda

9

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19 September 2017

language of work or name

English

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publication date

23 January 2006

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

281

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12

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19 September 2017

7890-7898

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Intramembrane proteolysis: theme and variations.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513250200

The roles of receptor and ligand endocytosis in regulating Notch signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513250200

Regulation of notch signaling activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Signalling downstream of activated mammalian Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

RBP-L, a transcription factor related to RBP-Jkappa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

kuzbanian-mediated cleavage of Drosophila Notch

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513250200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513250200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Intramembrane proteolysis by presenilin and presenilin-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Specific Compositions of Amyloid-β Peptides as the Determinant of Toxic β-Aggregation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513250200

Jagged: a mammalian ligand that activates Notch1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513250200

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513250200

21 January 2018

Identifiers

DOI

10.1074/JBC.M513250200

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19 September 2017

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