Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides (Q30811532)

26 June 2017

title

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides (English)

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26 June 2017

main subject

transmembrane protein

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6

Dennis J Selkoe

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26 June 2017

Jimin Zhang

1

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26 June 2017

Wenjuan Ye

2

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26 June 2017

Rong Wang

3

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26 June 2017

Michael S Wolfe

4

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26 June 2017

Barry D Greenberg

5

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26 June 2017

language of work or name

English

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publication date

11 February 2002

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Journal of Biological Chemistry

26 June 2017

published in

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26 June 2017

volume

277

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26 June 2017

issue

17

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26 June 2017

page(s)

15069-15075

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

26 June 2017

cites work

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Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

21 January 2018

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein

21 January 2018

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21 January 2018

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21 January 2018

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Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 January 2018

1 reference

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

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21 January 2018

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21 January 2018

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21 January 2018

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Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

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The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

21 January 2018

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Mutations in the transmembrane domain of APP altering gamma-secretase specificity

21 January 2018

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gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

21 January 2018

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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

21 January 2018

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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

21 January 2018

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Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M105375200

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26 June 2017

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