Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B. (Q40343692)

19 September 2017

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B. (English)

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19 September 2017

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5

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11 June 2020

Paola Fisicaro

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Valeria Barili

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Barbara Montanini

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Francesca Guerrieri

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Pietro Lampertico

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Gabriele Missale

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Massimo Levrero

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Carlo Ferrari

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Marco Massari

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Debora Salerno

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10

M Cristina Cavallo

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12

Tiziana Giuberti

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16

Simone Ottonello

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11 June 2020

author name string

Greta Acerbi

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11 June 2020

Carolina Boni

8

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11 June 2020

Glenda Grossi

11

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11 June 2020

language of work or name

English

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publication date

6 February 2017

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19 September 2017

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11 June 2020

volume

23

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11 June 2020

page(s)

327-336

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11 June 2020

issue

3

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https://scigraph.springernature.com/pub.10.1038/nm.4275

11 June 2020

exact match

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cites work

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Restoring function in exhausted CD8 T cells during chronic viral infection

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Regulatory T cells and viral liver disease

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Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection

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Role of regulatory T cells during virus infection

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Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation

21 January 2018

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Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection

21 January 2018

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Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV.

21 January 2018

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Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.

21 January 2018

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The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function

21 January 2018

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Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

21 January 2018

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Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation

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Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells

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A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity.

21 January 2018

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HSP70 mediates degradation of the p65 subunit of nuclear factor κB to inhibit inflammatory signaling

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Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

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T cell metabolism drives immunity

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Proteasomes in immune cells: more than peptide producers?

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Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

21 January 2018

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Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases?

21 January 2018

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Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression

21 January 2018

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21 January 2018

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Mitochondria: more than just a powerhouse

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21 January 2018

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Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

21 January 2018

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Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.

21 January 2018

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Molecular and functional profiling of memory CD8 T cell differentiation.

21 January 2018

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Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion

21 January 2018

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Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8(+) T cells

21 January 2018

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21 January 2018

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Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host.

21 January 2018

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The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions

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Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation

21 January 2018

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

21 January 2018

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Electron transport complex I is required for CD8+ T cell function.

21 January 2018

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Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

21 January 2018

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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

21 January 2018

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Identifiers

DOI

10.1038/NM.4275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28165481%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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